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2
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3
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Hypermethylation pattern of ESR and PgR genes and lacking estrogen and progesterone receptors in human breast cancer tumors: ER/PR subtypes.人类乳腺癌肿瘤中 ESR 和 PgR 基因的高甲基化模式和缺乏雌激素和孕激素受体：ER/PR 亚型。
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本文引用的文献

1
DNA methylation and breast tumor clinicopathological features: The Western New York Exposures and Breast Cancer (WEB) study.DNA甲基化与乳腺肿瘤临床病理特征：纽约西部暴露因素与乳腺癌（WEB）研究
Epigenetics. 2016 Sep;11(9):643-652. doi: 10.1080/15592294.2016.1192735. Epub 2016 May 31.
2
Mediation of Racial and Ethnic Disparities in Estrogen/Progesterone Receptor-Negative Breast Cancer by Socioeconomic Position and Reproductive Factors.社会经济地位和生殖因素对雌激素/孕激素受体阴性乳腺癌种族和民族差异的介导作用
Am J Epidemiol. 2016 May 15;183(10):884-93. doi: 10.1093/aje/kwv226. Epub 2016 Apr 13.
3
An integrated genomics analysis of epigenetic subtypes in human breast tumors links DNA methylation patterns to chromatin states in normal mammary cells.对人类乳腺肿瘤表观遗传亚型的综合基因组分析将DNA甲基化模式与正常乳腺细胞中的染色质状态联系起来。
Breast Cancer Res. 2016 Feb 29;18(1):27. doi: 10.1186/s13058-016-0685-5.
4
DNA methylation and hormone receptor status in breast cancer.乳腺癌中的DNA甲基化与激素受体状态
Clin Epigenetics. 2016 Feb 16;8:17. doi: 10.1186/s13148-016-0184-7. eCollection 2016.
5
Breast cancer statistics, 2015: Convergence of incidence rates between black and white women.乳腺癌统计数据，2015：黑人和白人女性发病率趋同。
CA Cancer J Clin. 2016 Jan-Feb;66(1):31-42. doi: 10.3322/caac.21320. Epub 2015 Oct 29.
6
Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation.探索启动子、基因内和基因间区域的DNA甲基化变化，作为乳腺癌形成过程中的早期和晚期事件。
BMC Cancer. 2015 Oct 29;15:816. doi: 10.1186/s12885-015-1777-9.
7
DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer.导管原位癌中的DNA甲基化与浸润性乳腺癌的未来发展相关。
Clin Epigenetics. 2015 Jul 25;7(1):75. doi: 10.1186/s13148-015-0094-0. eCollection 2015.
8
Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis.乳腺癌进展为原位癌和浸润癌过程中的全基因组DNA甲基化谱及其对基因转录和预后的影响
Genome Biol. 2014;15(8):435. doi: 10.1186/PREACCEPT-2333349012841587. Epub 2014 Aug 22.
9
Race/ethnicity and disparities in mastectomy practice in the Breast Cancer Care in Chicago study.芝加哥乳腺癌护理研究中乳房切除术实践的种族/族裔与差异
Ann Surg Oncol. 2015 Jan;22(1):66-74. doi: 10.1245/s10434-014-3945-6. Epub 2014 Aug 19.
10
US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status.美国联合激素受体和 HER2 状态定义的乳腺癌亚型发病率。
J Natl Cancer Inst. 2014 Apr 28;106(5):dju055. doi: 10.1093/jnci/dju055.

候选基因 DNA 甲基化与乳腺癌特征和肿瘤进展的关联。

Candidate gene DNA methylation associations with breast cancer characteristics and tumor progression.

机构信息

Division of Epidemiology & Biostatistics, University of Illinois at Chicago School of Public Health, Chicago, IL 60612, USA.

Department of Pathology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA.

出版信息

Epigenomics. 2018 Apr 1;10(4):367-378. doi: 10.2217/epi-2017-0119. Epub 2018 Mar 12.

DOI:10.2217/epi-2017-0119
PMID:29528252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5925433/
Abstract

AIM

We examined methylation patterns with aggressive tumor phenotypes and investigated demographic, socioeconomic and reproductive predictors of gene methylation.

MATERIALS & METHODS: Pyrosequencing quantified methylation of BRCA1, EGFR, GSTM2, RASSF1, TFF1 and Sat 2. We used quantile regression models to calculate adjusted median methylation values by estrogen and progesterone receptor (ER/PR) status. Bivariate associations between participant characteristics and methylation were examined.

RESULTS

Higher percent methylation of GSTM2 was observed in ER/PR-negative compared with ER/PR-positive tumors in ductal carcinoma in situ (14 vs 2%) and invasive (35 vs 3%) tissue components. Trends in aberrant GSTM2 methylation across tissue components were stronger among ER/PR-negative tumors (p-interaction <0.001). Black women were more likely to have ER/PR-negative tumors (p = 0.01) and show hypermethylation of GSTM2 compared with other women (p = 0.05).

CONCLUSION

GSTM2 promoter hypermethylation may serve as a potential biomarker of aggressive tumor development and a mechanism for ER/PR-negative tumor progression.

摘要

目的

我们研究了具有侵袭性肿瘤表型的甲基化模式，并探讨了基因甲基化的人口统计学、社会经济学和生殖预测因素。

材料与方法

焦磷酸测序定量检测 BRCA1、EGFR、GSTM2、RASSF1、TFF1 和 Sat2 的甲基化。我们使用分位数回归模型，根据雌激素和孕激素受体（ER/PR）状态计算调整后的中位甲基化值。检验了参与者特征与甲基化之间的双变量关联。

结果

在导管原位癌（DCIS）和浸润性组织成分中，与 ER/PR 阳性肿瘤相比，GSTM2 高甲基化的百分比在 ER/PR 阴性肿瘤中更高（分别为 14%和 2%）。在 ER/PR 阴性肿瘤中，GSTM2 异常甲基化的趋势更强（p 交互<0.001）。与其他女性相比，黑人女性更有可能患有 ER/PR 阴性肿瘤（p=0.01），并且 GSTM2 呈高甲基化状态（p=0.05）。

结论

GSTM2 启动子的过度甲基化可能是侵袭性肿瘤发展的潜在生物标志物，也是 ER/PR 阴性肿瘤进展的机制。