癌症光动力治疗中的剂量测量

Dose measurements in photodynamic therapy of cancer.

作者信息

Profio A E, Doiron D R

出版信息

Lasers Surg Med. 1987;7(1):1-5. doi: 10.1002/lsm.1900070102.

DOI:10.1002/lsm.1900070102

Abstract

A theory and method for prediction and measurement of the effective absorbed dose in photodynamic therapy of cancer is presented. The method depends on measuring the concentration of the photosensitizer (such as dihematorporphyrin ether), the flux density of the light, and the relative photodynamic effectiveness. Previous, less exact methods relied on specifying the drug dosage and delay after injection and or the irradiance at the surface or power from an interstitial fiber. The new formulation should permit closer control of the effective absorbed dose and better clinical results with photodynamic therapy.

摘要

提出了一种用于癌症光动力治疗中有效吸收剂量预测和测量的理论与方法。该方法依赖于测量光敏剂（如二血卟啉醚）的浓度、光通量密度和相对光动力效能。以前不太精确的方法依赖于指定药物剂量、注射后的延迟时间以及表面辐照度或间质光纤的功率。新的公式应能更精确地控制有效吸收剂量，并在光动力治疗中取得更好的临床效果。