Bernstein E F, Thomas G F, Smith P D, Mitchell J B, Glatstein E, Kantor G R, Spielvogel R L, Maiese S C, Russo A
Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md.
Arch Dermatol. 1990 Oct;126(10):1303-7.
Differences in skin pigmentation may significantly affect light penetration during photodynamic therapy. This study evaluated the effect of skin pigmentation on dermatotoxic reaction to photodynamic therapy utilizing the photosensitizer dihematoporphyrin ether. Black and white guinea pigs were given 10 mg/kg of dihematoporphyrin ether, depilated, and treated 48 hours after injection with 30 mW/cm2 of 514-nm light. Eschar formation was observed on white skin at an average light dose of 26 J/cm2, whereas black skin showed similar changes at 58 J/cm2. Microscopically, superficial necrosis corresponded to the gross changes noted. Our results agree with data describing the difficulty of treating pigmented lesions such as malignant melanoma with photodynamic therapy. This further suggests that higher light doses may be required to treat superficial lesions and produce skin photosensitivity in dark-skinned individuals.
皮肤色素沉着的差异可能会在光动力疗法期间显著影响光线穿透。本研究评估了利用光敏剂双血卟啉醚时皮肤色素沉着对光动力疗法皮肤毒性反应的影响。给黑色和白色豚鼠注射10mg/kg双血卟啉醚，进行脱毛处理，并在注射48小时后用30mW/cm²的514nm光进行治疗。白色皮肤在平均光剂量为26J/cm²时观察到焦痂形成，而黑色皮肤在58J/cm²时出现类似变化。显微镜下，浅表坏死与所观察到的大体变化相符。我们的结果与描述用光动力疗法治疗色素沉着病变（如恶性黑色素瘤）困难的数据一致。这进一步表明，治疗深色皮肤个体的浅表病变并使其产生皮肤光敏性可能需要更高的光剂量。
