Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.
Department of Neurology, University California San Francisco, USA.
J Physiol. 2018 Dec;596(23):5655-5664. doi: 10.1113/JP274938. Epub 2018 Apr 16.
Central nervous system homeostasis is maintained by cellular barriers that protect the brain from external environmental changes and protect the CNS from harmful molecules and pathogens in the blood. Historically, for many years these barriers were thought of as immature, with limited functions, during brain development. In this review, we will present advances in the understanding of the barrier systems during development and evidence to show that in fact the barriers serve many important neurodevelopmental functions and that fetal and newborn brains are well protected. We will also discuss how ischaemic injury or systemic inflammation may breach the integrity of the barriers in the developing brain.
中枢神经系统的内环境稳定由细胞屏障维持，这些屏障可保护大脑免受外部环境变化的影响，并防止血液中的有害物质和病原体进入中枢神经系统。长期以来，人们一直认为这些屏障在脑发育过程中不成熟，功能有限。在这篇综述中，我们将介绍在发育过程中对这些屏障系统的认识的进展，并提供证据表明，事实上，这些屏障具有许多重要的神经发育功能，胎儿和新生儿的大脑受到很好的保护。我们还将讨论缺血性损伤或全身炎症如何破坏发育中大脑的屏障完整性。
