Lee R W, Gay R G, Moffett C, Johnson D G, Goldman S
Life Sci. 1987 May 18;40(20):2025-30. doi: 10.1016/0024-3205(87)90294-3.
Serum levels of atrial natriuretic peptide (ANP) are elevated in chronic heart failure presumably due to dilatation of the left atrium resulting from increases in intracardiac pressures. To define the time course of changes in serum ANP levels and to determine the relationship to left ventricular end-diastolic pressure, rats were subjected to coronary artery ligation to produce myocardial infarction and left ventricular failure. Atrial natriuretic peptide levels were measured weekly for four weeks thereafter. In rats with myocardial infarction and elevation of left ventricular end-diastolic pressure there was no change in ANP levels at 7 and 14 days. However, at day 21 and 28, ANP levels were elevated more than 3 fold. There was a correlation between ANP levels and left ventricular end-diastolic pressures. There was no correlation between ANP levels and right atrial pressures or serum sodium concentrations. We conclude that the chronic elevation of left ventricular end-diastolic pressure is required to produce an increase in ANP after myocardial infarction which results in chronic heart failure.
慢性心力衰竭患者血清心房利钠肽（ANP）水平升高，这可能是由于心内压升高导致左心房扩张所致。为了确定血清ANP水平变化的时间进程，并确定其与左心室舒张末期压力的关系，对大鼠进行冠状动脉结扎以诱发心肌梗死和左心室衰竭。此后每周测量一次心房利钠肽水平，持续四周。在发生心肌梗死且左心室舒张末期压力升高的大鼠中，第7天和第14天时ANP水平无变化。然而，在第21天和第28天，ANP水平升高了3倍多。ANP水平与左心室舒张末期压力之间存在相关性。ANP水平与右心房压力或血清钠浓度之间无相关性。我们得出结论，心肌梗死后导致慢性心力衰竭，需要左心室舒张末期压力长期升高才能使ANP增加。
