Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
China National Clinical Research Center for Neurological Diseases, Beijing, China.
CNS Neurosci Ther. 2018 Dec;24(12):1149-1155. doi: 10.1111/cns.12846. Epub 2018 Mar 12.
Little is known about the performance of the maximally treated intracerebral hemorrhage (max-ICH) score in predicting unfavorable long-term functional outcome and death in patients with intracerebral hemorrhage (ICH) in China. We aimed to validate the performance of the max-ICH score and compared it with other recognized scores.
We derived data from the China National Stroke Registry (CNSR). Receiver-operating characteristic (ROC) analysis and Hosmer-Lemeshow test were used to measure the score performance. We compared the performance of max-ICH score with six recognized models, including the ICH score, ICH functional outcome score (ICH-FOS), Essen-ICH score, modified intracerebral hemorrhage (MICH) score, intracerebral hemorrhage grading scale (ICH-GS), and functional outcome (FUNC) score.
A total of 2581 patients with spontaneous ICH were enrolled in the study. The max-ICH score was similar or superior to the six existing scores in predicting long-term unfavorable functional outcome after ICH with good discrimination (AUC 0.83, 95% confidence interval [CI] 0.81-0.84) and calibration (Hosmer-Lemeshow P = 0.19). For predicting death, the AUC of max-ICH was 0.81 (95% CI 0.79-0.83).
The easy-to-use max-ICH score is a reliable tool to predict unfavorable long-term (12-month) functional outcome and death after intracerebral hemorrhage in the Chinese population.
对于中国脑出血（ICH）患者，最大限度治疗的脑出血评分（max-ICH）在预测不良长期功能结局和死亡方面的表现知之甚少。我们旨在验证 max-ICH 评分的表现，并将其与其他公认的评分进行比较。
我们从中国国家卒中登记处（CNSR）中获得数据。使用受试者工作特征（ROC）分析和 Hosmer-Lemeshow 检验来衡量评分表现。我们将 max-ICH 评分与六个公认的模型（包括 ICH 评分、ICH 功能结局评分（ICH-FOS）、Essen-ICH 评分、改良脑出血评分（MICH）、脑出血分级量表（ICH-GS）和功能结局评分（FUNC））的表现进行了比较。
共纳入 2581 例自发性 ICH 患者。max-ICH 评分在预测脑出血后长期不良功能结局方面与六个现有评分相似或更优，具有良好的区分度（AUC 为 0.83，95%置信区间 [CI]为 0.81-0.84）和校准度（Hosmer-Lemeshow P=0.19）。对于预测死亡，max-ICH 的 AUC 为 0.81（95%CI 0.79-0.83）。
易于使用的 max-ICH 评分是一种可靠的工具，可用于预测中国人群脑出血后不良的长期（12 个月）功能结局和死亡。
