Morita-Baylis-Hillman 加合物的潜在抗氧化活性。

Potential antioxidant activity of Morita-Baylis-Hillman adducts.

机构信息

Laboratoire de Chimie Organique Structurale LR99ES14, Faculté des Sciences de Tunis, Université de Tunis El Manar, Campus Universitaire, 2092 Tunis, Tunisia.

Laboratoire de Biotechnologie Moléculaire des Eucaryotes, Centre de Biotechnologie de Sfax, Université de Sfax, Tunisia.

出版信息

Bioorg Chem. 2018 Aug;78:24-28. doi: 10.1016/j.bioorg.2018.03.004. Epub 2018 Mar 3.

DOI:10.1016/j.bioorg.2018.03.004

PMID:29529518

Abstract

The wide variety of potent biological activities of Morita-Baylis-Hillman adducts (MBH) encouraged us to synthesize new series of products belonging to this class of compounds, possessing different functionalities and exhibiting potential antioxidant activity. As part of our on-going program on targeting molecules with antioxidant activity, we describe herein different DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activities of MBH alcohols and their derivatives including acetates, phosphonates and hydrazonophosphonates. The obtained results showed that the strongest DPPH radical scavenging activity was observed in the case of hydrazonophosphonates in comparison to the other MBH derivatives.

摘要

Morita-Baylis-Hillman 加合物（MBH）具有广泛的强效生物活性，这促使我们合成了属于这一类化合物的新系列产品，它们具有不同的官能团，并表现出潜在的抗氧化活性。作为我们针对具有抗氧化活性的目标分子的持续计划的一部分，我们在此描述了 MBH 醇及其衍生物（包括乙酸酯、膦酸酯和肼基膦酸酯）的不同 DPPH（2,2-二苯基-1-苦基肼基）清除活性。所得到的结果表明，在肼基膦酸酯的情况下，与其他 MBH 衍生物相比，观察到最强的 DPPH 自由基清除活性。