Kuhn J M, Laudat M H, Wolf L M, Luton J P
Presse Med. 1987 Apr 18;16(14):675-9.
Male hypogonadism is characterized by a lowering of plasma testosterone level below the lower limit of physiological variations. Conversely, some adult males, apparently eugonadic, have a plasma testosterone level much higher than normally. In most cases, male hypertestosteronaemia - defined by a plasma testosterone level above 13 ng/ml and due to various physiopathological mechanisms - is part of a wider pathological context. It betrays hyperandrogenism (elevated free testosterone) during treatment with androgens or chorionic gonadotropic hormone. In other cases, it seems to underlie a relative hypoandrogenism with rise of testosterone bound to transport proteins and/or excess of oestrogens. Hypertestosteronaemia therefore appears as a biochemical sign not to be ignored, but it also suggests that men with abnormally high testosterone levels present with new pathology and that aetiological investigations are necessary.
男性性腺功能减退的特征是血浆睾酮水平降至生理变化下限以下。相反，一些成年男性，表面上性腺功能正常，但其血浆睾酮水平却远高于正常水平。在大多数情况下，男性高雄激素血症（由血浆睾酮水平高于13 ng/ml定义，且由各种生理病理机制引起）是更广泛病理背景的一部分。它在使用雄激素或绒毛膜促性腺激素治疗期间表现为雄激素过多（游离睾酮升高）。在其他情况下，它似乎是与结合转运蛋白的睾酮升高和/或雌激素过量相关的相对性雄激素缺乏的基础。因此，高雄激素血症似乎是一个不可忽视的生化指标，但这也表明睾酮水平异常高的男性存在新的病理情况，病因调查是必要的。
