Cussins Jessica, Lowthorp Leah
a Center for Genetics and Society , Berkeley , CA , USA.
New Bioeth. 2018 Apr;24(1):74-94. doi: 10.1080/20502877.2018.1443409.
'Mitochondrial replacement' and 'germline gene editing' are relatively new techniques that represent a significant moral, technological, and legal threshold, as they would introduce permanent and heritable changes to the human gene pool. This article examines the close relationship between these two technologies over time, considering what regulatory lessons can be learned from the former as attention turns to the latter. It argues that the UK's 'mitochondrial replacement' approval process should not be taken as a model for the wider regulation of germline gene editing, and that policy-making needs to contend with a comprehensive picture of the social and political meaning of these technologies in the world.
“线粒体替代”和“生殖系基因编辑”是相对较新的技术，它们代表了一个重大的道德、技术和法律门槛，因为它们将给人类基因库带来永久性和可遗传的变化。本文考察了这两种技术随时间推移的紧密关系，思考随着注意力转向后者，能从前者吸取哪些监管方面的经验教训。文章认为，英国的“线粒体替代”审批程序不应被视为对生殖系基因编辑进行更广泛监管的模式，政策制定需要应对这些技术在全球范围内的社会和政治意义的全面情况。
