Department of Philosophy, Faculty of Liberal Arts, Adolfo Ibáñez University, Vina Del Mar, Chile.
Oxford Uehiro Centre for Practical Ethics, Oxford University, Oxford, United Kingdom of Great Britain and Northern Ireland.
Bioethics. 2021 Jul;35(6):563-573. doi: 10.1111/bioe.12878. Epub 2021 May 5.
Genetic engineering has been a topic of discussion for over 50 years, but it is only recently that gene editing has become a reality. CRISPR biotechnologies have made gene editing much safer, precise and feasible. We have witnessed the first cases of human germline genetic modification resulting in live births, conducted by He Jiankui. In this paper, we will analyse He Jiankui's case in relation to one of the most difficult problems in procreative ethics (or the ethics of future generations): the non-identity problem. We believe that this analysis will help us to understand the ethics involved in gene editing and hopefully allow for a better, more philosophically grounded legislation on CRISPR and other gene-editing technologies.
基因编辑技术已经成为讨论的话题超过 50 年，但直到最近，基因编辑才成为现实。CRISPR 生物技术使得基因编辑更加安全、精确和可行。我们已经见证了首例人类生殖细胞基因编辑导致活体出生的案例，这是由贺建奎完成的。在本文中，我们将分析贺建奎的案例与生殖伦理（或后代伦理）中最困难的问题之一：非同一性问题。我们相信，这种分析将有助于我们理解基因编辑所涉及的伦理问题，并希望为 CRISPR 和其他基因编辑技术制定更好、更有哲学基础的立法。
