乳糜泻与重症肌无力风险——基于全国人口的研究
Celiac disease and risk of myasthenia gravis - nationwide population-based study.
作者信息
Thawani Sujata P, Brannagan Thomas H, Lebwohl Benjamin, Green Peter H R, Ludvigsson Jonas F
机构信息
Department of Neurology, New York University School of Medicine, New York, NY, USA.
Peripheral Neuropathy Center, Neurological Institute, Columbia University, College of Physicians and Surgeons, New York, NY, USA.
出版信息
BMC Neurol. 2018 Mar 12;18(1):28. doi: 10.1186/s12883-018-1035-2.
BACKGROUND
Case reports suggest there may be an association between celiac disease (CD) and myasthenia gravis (MG).
METHODS
We identified 29,086 individuals with CD in Sweden from 1969 to 2008. We compared these individuals with 144,480 matched controls. Hazard ratios (HRs) for future MG (identified through ICD codes) were estimated using Cox regression.
RESULTS
During 326,376 person-years of follow-up in CD patients, there were 7 MG cases (21/million person-years) compared to 22 MG cases in controls during 1,642,273 years of follow-up (14/million person-years) corresponding to a HR of 1.48 (95% CI = 0.64-3.41). HRs did not differ when stratifying for age, sex or calendar period. HRs were highest in the first year after follow-up, though insignificant. Individuals with CD were at no increased risk of MG more than 5 years after CD diagnosis (HR = 0.70; 95% CI = 0.16-3.09).
CONCLUSION
This study found no increased risk of MG in patients with CD.
背景
病例报告表明乳糜泻（CD）与重症肌无力（MG）之间可能存在关联。
方法
我们在瑞典确定了1969年至2008年期间的29086例CD患者。我们将这些患者与144480例匹配的对照进行比较。使用Cox回归估计未来MG（通过国际疾病分类代码确定）的风险比（HR）。
结果
在CD患者326376人年的随访期间，有7例MG病例（每百万人年21例），而在1642273人年的随访期间，对照组有22例MG病例（每百万人年14例），对应的HR为1.48（95%CI=0.64-3.41）。按年龄、性别或日历期分层时，HR没有差异。随访后第一年的HR最高，尽管不显著。CD诊断后5年以上，CD患者发生MG的风险没有增加（HR=0.70；95%CI=0.16-3.09）。
结论
本研究发现CD患者发生MG的风险没有增加。
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