Department of Pharmaceutics, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK.
Department of Mechanical Engineering, Imperial College London, London SW7 2AZ, UK.
Eur J Pharm Biopharm. 2018 Jun;127:355-365. doi: 10.1016/j.ejpb.2018.02.032. Epub 2018 Mar 9.
Nail patches have a potential role as drug carriers for the topical treatment of nail diseases such as onychomycosis, a common condition. Our aim was therefore to develop a systematic and novel approach to the formulation of a simple drug-in-adhesive ungual patch. Twelve pressure-sensitive adhesives (PSAs), four backing membranes, two release liners and three drugs were screened for pharmaceutical and mechanical properties. From this initial screening, two PSAs, two drugs, one backing membrane and one release liner were selected for further investigation. Patches were prepared by solvent-casting and characterised. The patches had good uniformity of thickness and of drug content, and showed minimal drug crystallisation during six months of storage. Meanwhile, the drug stability in the patch upon storage and patch adhesion to the nail was influenced by the nature of the drug, the PSA and the backing membrane. The reported methodology paves the way for a systematic formulation of ungual nail patches to add to the armamentarium of nail medicines. Further, from this work, the best patch formulation has been identified.
甲贴片作为药物载体在局部治疗甲疾病，如甲真菌病（一种常见疾病）方面具有潜在的作用。因此，我们的目的是开发一种系统的、新颖的方法来制备简单的药物贴剂甲贴片。我们筛选了 12 种压敏胶 (PSA)、4 种背衬膜、2 种离型纸和 3 种药物，以评估它们的药物和机械性能。通过初步筛选，选择了两种 PSA、两种药物、一种背衬膜和一种离型纸进行进一步研究。通过溶剂浇铸法制备了贴片，并对其进行了特性评估。这些贴片具有良好的厚度均匀性和药物含量均匀性，并且在六个月的储存期间显示出最小的药物结晶。同时，药物在贴片中的稳定性以及贴片对指甲的黏附性受到药物性质、PSA 和背衬膜的影响。本研究报告的方法为系统地制备甲贴片奠定了基础，有望增加甲病药物的种类。此外，通过这项工作，我们确定了最佳的贴片配方。
