Wambach G, Hannekum A, Schmidt S, Kaufmann W, Dalichau H
Z Kardiol. 1987 Feb;76(2):76-80.
Plasma levels of atrial natriuretic peptide (ANP) and tissue content of the peptide were measured simultaneously in 18 patients with coronary heart disease (group A) and 10 patients with aortic or mitral dysfunction (group B) undergoing open heart surgery. Plasma levels of ANP were significantly higher in patients with valvular heart disease compared to those with coronary heart disease (816 +/- 246 pg/ml versus 232 +/- 58 pg/ml, p less than 0.005). Similarly, tissue levels of ANP in the right atrium of group B doubled that of group A (227 +/- 46 micrograms/g versus 129 +/- 15 micrograms/g, p less than 0.025). Plasma levels and tissue content of ANP were not correlated. However, plasma ANP levels and mean pulmonary artery pressure were positively correlated (r = 0.688, p less than 0.05). Chronic stimulation of ANP secretion leads to a tissue accumulation of natriuretic peptide in heart atrium.
在18例接受心脏直视手术的冠心病患者（A组）和10例主动脉或二尖瓣功能障碍患者（B组）中，同时测量了血浆心房利钠肽（ANP）水平和该肽的组织含量。与冠心病患者相比，瓣膜性心脏病患者的血浆ANP水平显著更高（816±246 pg/ml对232±58 pg/ml，p<0.005）。同样，B组右心房的ANP组织水平是A组的两倍（227±46微克/克对129±15微克/克，p<0.025）。ANP的血浆水平与组织含量不相关。然而，血浆ANP水平与平均肺动脉压呈正相关（r = 0.688，p<0.05）。ANP分泌的慢性刺激导致心房中利钠肽的组织蓄积。
