Lang R E, Dietz R, Merkel A, Unger T, Ruskoaho H, Ganten D
J Hypertens Suppl. 1986 Jun;4(2):S119-23.
The plasma concentrations of atrial natriuretic peptides (ANP) were measured during cardiac catheterization in 137 patients with heart disease. Atrial natriuretic peptides were elevated in all types of cardiac disease investigated, including valve disease, coronary heart disease and cardiomyopathy. The highest plasma ANP concentrations were found in patients with the most marked impairment of ventricular function and mitral valve disease. In patients with coronary heart disease, a significant, direct linear correlation was found between left ventricular filling pressure and plasma ANP concentrations (r = 0.42, P less than 0.001). Similarly, in patients with cardiomyopathy, a linear relationship was found between mean pulmonary artery pressure and plasma ANP concentration (r = 0.80, P less than 0.01). These observations suggest that measurement of ANP may be of value as a non-invasive humoral marker in the diagnosis of various cardiac diseases.
在137例心脏病患者进行心导管检查期间，测定了血浆心房利钠肽（ANP）浓度。在所研究的所有类型心脏病中，包括瓣膜病、冠心病和心肌病，心房利钠肽均升高。血浆ANP浓度最高的是心室功能和二尖瓣疾病受损最明显的患者。在冠心病患者中，左心室充盈压与血浆ANP浓度之间存在显著的直接线性相关性（r = 0.42，P<0.001）。同样，在心肌病患者中，平均肺动脉压与血浆ANP浓度之间也存在线性关系（r = 0.80，P<0.01）。这些观察结果表明，测定ANP作为一种非侵入性体液标志物，可能对各种心脏病的诊断有价值。
