Tchernev Georgi, Terziev Ivan
Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.
Onkoderma, Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
Open Access Maced J Med Sci. 2018 Feb 14;6(2):376-377. doi: 10.3889/oamjms.2018.108. eCollection 2018 Feb 15.
For the first time in the world medical literature, we describe a rare form of cutaneous dermatophytosis - a bullous form of Tinea incognito, classified by clinical picture, histopathological findings and an isolated infectious agent from the microbiological culture. After a thorough review of Medline/PubMed's relevant literature, we could not find similar cases of patients with Tinea incognito who are clinically presented with bullous lesions at the same time. Local application of corticosteroids in infants with unknown lesions may lead to progression of the underlying disease and may cause some serious problems in differential diagnosis aspect, while the clinical expression remains completely masked. Exactly for this reason, right at the beginning of the clinical complaints, a skin biopsy should be obligatorily performed in parallel with microbiological swabs. If there is no improvement after the local corticosteroid application, then diagnosis revision and change of the strategy of clinical behaviour would be appropriate to be done. The systemic treatment that we performed with Fluconazole 50 mg in combination with the local antimycotic agent for a 2-week period led to complete remission.
在世界医学文献中,我们首次描述了一种罕见的皮肤癣菌病形式——隐匿型体癣的大疱型,通过临床表现、组织病理学检查结果以及微生物培养分离出的感染病原体进行分类。在对Medline/PubMed的相关文献进行全面检索后,我们未发现隐匿型体癣患者同时出现大疱性皮损的类似病例。在皮损情况不明的婴儿中局部应用糖皮质激素可能会导致潜在疾病进展,并且在鉴别诊断方面可能会引发一些严重问题,而临床表现仍完全被掩盖。正是出于这个原因,在临床症状出现之初,应同时进行皮肤活检和微生物拭子检查。如果局部应用糖皮质激素后病情无改善,那么进行诊断修正并改变临床治疗策略是合适的。我们采用50毫克氟康唑联合局部抗真菌药物进行了为期2周的系统治疗,使病情完全缓解。