Farkhondeh Tahereh, Samarghandian Saeed, Shaterzadeh Yazdi Hanieh, Samini Fariborz
Cardiovascular Diseases Research Center, Birjand University of Medical SciencesBirjand, Iran.
Department of Basic Medical Sciences, Neyshabur University of Medical SciencesNeyshabur, Iran.
Am J Neurodegener Dis. 2018 Feb 5;7(1):1-10. eCollection 2018.
Flavonoids have been used in traditional medicine to promote human health. Crocin has been proposed to be effective in the management of the various diseases including the neurodegenerative diseases. Antiepileptic and anti-Alzheimer effects of crocin have also been indicated. The efficacy of crocis in the treatment of cerebral ischemia and traumatic brain injury was also confirmed by using animal models. Crocin treatment increased dopamine levels in the brain of experimental model of Parkinson's disease. In addition, crocin modulates the opioid system to decrease the withdrawal syndrome. Thus, the present study highlighted the effects of crocin on the nervous system and the underling mechanisms. This review also indicated that crocins can be considered as an effective candidate in the management of nervous system diseases due to their antioxidant and anti-inflammation effects.
类黄酮已被用于传统医学以促进人类健康。藏红花素被认为对包括神经退行性疾病在内的各种疾病的治疗有效。藏红花素的抗癫痫和抗阿尔茨海默病作用也已得到证实。使用动物模型也证实了藏红花素在治疗脑缺血和创伤性脑损伤方面的疗效。藏红花素治疗可提高帕金森病实验模型大脑中的多巴胺水平。此外，藏红花素可调节阿片系统以减轻戒断综合征。因此，本研究突出了藏红花素对神经系统的作用及其潜在机制。本综述还表明，由于其抗氧化和抗炎作用，藏红花素可被视为治疗神经系统疾病的有效候选药物。
