Li Jing, Sun Lili, Fang Fang, Morshedi Mohammadmatin
Sports Health Technology College, Jilin Sports University, Changchun, Jilin, 130022, China.
Jilin Sports University, Changchun, Jilin, 130022, China.
J Neuroimmune Pharmacol. 2025 Jun 30;20(1):69. doi: 10.1007/s11481-025-10228-z.
The hippocampus, a vital brain region, orchestrates numerous critical functions including memory, learning, stress response, and emotional regulation. Structural changes in the hippocampus due to prolonged stress exposure can precipitate cognitive decline and behavioral deficits. Recent studies have illuminated the restorative influence of physical fitness on the hippocampus; notably, exercise enhances memory, learning, hippocampal architecture, neurogenesis, and synaptic plasticity. A key mediator in these processes is the brain-derived neurotrophic factor (BDNF), which facilitates synaptic improvements and overall brain health following exercise. Concurrently, bioactive plant compounds such as curcumin, resveratrol, and crocin have emerged as potent therapeutic agents for neurodegenerative disorders, credited with improving memory, synaptic plasticity, and overall brain function, without the adverse effects associated with synthetic drugs. These natural compounds potentially exert their neuroprotective effects through various mechanisms including neurotransmitter regulation, oxidative stress alleviation, and stimulation of the BDNF-cyclic AMP response element binding protein (CREB) signaling pathway. Given the individual benefits of exercise and bioactive plant compounds, this review proposes a synergistic approach combining both modalities, aimed at developing novel, efficacious neuroprotective interventions. By harnessing the intertwined benefits of physical activity and plant-derived therapies, we outline a compelling case for their combined utility in fortifying hippocampal function and combating neurodegenerative conditions. In this review, we combined the benefits of exercise and therapy with bioactive plant components to create a neuroprotective drug.
海马体是大脑的一个重要区域，协调着众多关键功能，包括记忆、学习、应激反应和情绪调节。长期暴露于压力下导致的海马体结构变化会引发认知能力下降和行为缺陷。最近的研究揭示了身体健康对海马体的恢复性影响；值得注意的是，运动能增强记忆、学习能力、海马体结构、神经发生和突触可塑性。这些过程中的一个关键介质是脑源性神经营养因子（BDNF），它在运动后促进突触改善和整体大脑健康。同时，姜黄素、白藜芦醇和藏红花素等生物活性植物化合物已成为神经退行性疾病的有效治疗剂，它们能够改善记忆、突触可塑性和整体大脑功能，且没有合成药物的副作用。这些天然化合物可能通过多种机制发挥其神经保护作用，包括神经递质调节、减轻氧化应激以及刺激BDNF-环磷酸腺苷反应元件结合蛋白（CREB）信号通路。鉴于运动和生物活性植物化合物各自的益处，本综述提出了一种将这两种方式结合的协同方法，旨在开发新型、有效的神经保护干预措施。通过利用体育活动和植物源性疗法的相互交织的益处，我们阐述了它们在强化海马体功能和对抗神经退行性疾病方面联合应用的令人信服的理由。在本综述中，我们将运动和疗法的益处与生物活性植物成分相结合，以创建一种神经保护药物。
