Clowes A W, Zacharias R K, Kirkman T R
Am J Surg. 1987 May;153(5):501-4. doi: 10.1016/0002-9610(87)90802-6.
Synthetic arterial grafts fail because of thrombosis. Rapid endothelial coverage would be expected to generate a minimally thrombogenic surface and reduce the rate of failure. We investigated the possibility that such a lining could be established by transmural capillary ingrowth in polytetrafluoroethylene (30 or 60 micron internodal distance) and Dacron baboon aortoiliac grafts of 4 mm in diameter and 5 to 7 cm in length. All grafts demonstrated endothelial ingrowth from the cut edges of adjacent artery. The central portions of the 30 micron polytetrafluoroethylene grafts were still not healed at 3 months. Two of six Dacron grafts were healed 1 month postoperatively and all were healed at 3 months, whereas all 60 micron polytetrafluoroethylene grafts were healed 2 weeks postoperatively. At early follow-up, islands of endothelium were seen in the middle of the 60 micron polytetrafluoroethylene and Dacron grafts. These observations support the concept that transmural migration of capillaries can provide multiple sources of endothelium and early endothelial coverage of porous synthetic arterial grafts. This response is affected by the porosity and possibly the thrombogenicity of the graft material.
合成动脉移植物因血栓形成而失效。快速的内皮覆盖有望形成一个血栓形成倾向最小的表面并降低失败率。我们研究了在直径4毫米、长度5至7厘米的聚四氟乙烯（节间距离30或60微米）和涤纶狒狒主髂动脉移植物中通过跨壁毛细血管向内生长来建立这样一层内膜的可能性。所有移植物均显示有来自相邻动脉切缘的内皮向内生长。30微米聚四氟乙烯移植物的中央部分在3个月时仍未愈合。六个涤纶移植物中有两个在术后1个月愈合，所有移植物在3个月时均愈合，而所有60微米聚四氟乙烯移植物在术后2周愈合。在早期随访中，在60微米聚四氟乙烯和涤纶移植物的中部可见内皮岛。这些观察结果支持这样一种概念，即毛细血管的跨壁迁移可为多孔合成动脉移植物提供多个内皮来源并实现早期内皮覆盖。这种反应受移植物材料的孔隙率以及可能的血栓形成倾向影响。
