C8-鸟嘌呤修饰：对 Z-DNA 形成的影响及其在癌症中的作用。

C8-Guanine modifications: effect on Z-DNA formation and its role in cancer.

机构信息

Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Thailand.

出版信息

Org Biomol Chem. 2018 Mar 28;16(13):2198-2209. doi: 10.1039/c8ob00030a.

DOI:10.1039/c8ob00030a

PMID:29532848

Abstract

Base modifications are known to affect the structure and function of DNA. C8-guanine adducts from various carcinogenic compounds have been shown to be potent Z-DNA inducers. Hence, it has been hypothesized that Z-DNA plays a role in cancer and other genetic diseases. In this comprehensive review, Z-DNA and the effect of prevalent C8-guanine adducts on the B-Z transition are addressed. The discoveries of Z-DNA binding proteins including ADAR1, E3L, DLM1, and PKZ have suggested the relevance of Z-DNA in living systems. In addition, increasing evidence on the Z-DNA connection to gene transcription and inhibition reveals potential biological functions of the left-handed DNA. Finally, C8-guanine adducts that promote Z-DNA formation can be used as a tool to explore the Z-DNA function and its role in carcinogenesis.

摘要

碱基修饰已知会影响 DNA 的结构和功能。已证实，来自各种致癌化合物的 C8-鸟嘌呤加合物是有效的 Z-DNA 诱导剂。因此，人们假设 Z-DNA 在癌症和其他遗传疾病中发挥作用。在这篇全面的综述中，讨论了 Z-DNA 以及流行的 C8-鸟嘌呤加合物对 B-Z 转变的影响。Z-DNA 结合蛋白（包括 ADAR1、E3L、DLM1 和 PKZ）的发现表明 Z-DNA 在生命系统中的相关性。此外，越来越多的证据表明 Z-DNA 与基因转录和抑制的联系揭示了左手 DNA 的潜在生物学功能。最后，促进 Z-DNA 形成的 C8-鸟嘌呤加合物可用作探索 Z-DNA 功能及其在致癌作用中的作用的工具。