Iserson K V, Criss E A, Wright A L
Am J Emerg Med. 1987 May;5(3):227-31. doi: 10.1016/0735-6757(87)90327-5.
The seroprevalence of hepatitis B virus (HBV) markers in emergency physicians has been shown to be approximately 13%, roughly three times the prevalence in the general population. Frequent contact with blood and body secretions of potentially infectious patients undoubtedly is a major factor in the increased seroprevalence and risk of hepatitis B. The potential sequelae of HBV infection include chronic active hepatitis, cirrhosis, primary hepatocellular carcinoma, and development of the chronic carrier state, any of which may have a devastating impact on the personal health and professional career of the emergency physician. A vaccine against hepatitis B has been available since 1982 and has been found to be effective in approximately 90% of vaccinees. The vaccine is generally well tolerated; the most common side effects are reactions at the injection site, although systemic side effects may occur. The risk of serious illness due to the vaccine is very low. Using a risk/benefit analysis to assess the risks of hepatitis B and the risks and benefits of HBV vaccination, it is clear that HBV vaccination should be accepted by the emergency physician to minimize the risk of contracting hepatitis B.
急诊医生中乙肝病毒(HBV)标志物的血清流行率已显示约为13%,大约是普通人群流行率的三倍。频繁接触潜在感染患者的血液和身体分泌物无疑是血清流行率增加及感染乙肝风险升高的一个主要因素。HBV感染的潜在后果包括慢性活动性肝炎、肝硬化、原发性肝细胞癌以及慢性携带者状态的形成,其中任何一种情况都可能对急诊医生的个人健康和职业生涯产生毁灭性影响。自1982年以来就有乙肝疫苗,并且已发现该疫苗对约90%的接种者有效。该疫苗一般耐受性良好;最常见的副作用是注射部位的反应,不过也可能出现全身性副作用。因疫苗导致重病的风险非常低。通过风险/效益分析来评估乙肝风险以及HBV疫苗接种的风险和益处,很明显急诊医生应该接受HBV疫苗接种,以将感染乙肝的风险降至最低。