Żychowska Iwona, Suszek Dorota, Dryglewska Magdalena, Majdan Maria
Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Poland.
Adv Clin Exp Med. 2018 Mar;27(3):379-382. doi: 10.17219/acem/68291.
Systemic lupus erythematosus (SLE) is characterized by alternating periods of activity and remission. A portion of the patients suffers from the chronically active form of the disease. The search for clinically useful markers of its activity is ongoing. At present, it is suggested that β2-microglobulin (β2M) may be useful in assessing SLE activity.
The objective of the paper was to investigate the relationship between serum β2M concentration and SLE activity.
The study group consisted of 69 SLE patients (62 women and 7 men), aged 34.5 ±11 years (19-69). Patients with kidney failure and infection were excluded from the study group. The concentration of β2M was measured using an ELISA test. SLE activity was assessed with Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), and by measuring the levels of C3 and C4 complement components, anti-double stranded DNA antibodies (anti-dsDNA antibodies) and β2M. The relationship between β2M and the clinical manifestation of SLE was also covered in the study.
The study revealed a statistically significant correlation between β2M concentration and SLEDAI-2K disease activity index (p < 0.05; r = 0.6), anti-dsDNA titer (p < 0.05; r = 0.3), and C4 component serum level (p < 0.05; r = -0.3). β2M concentration was significantly higher in patients with arthritis and/or myositis (p = 0.005), vasculitis (p = 0.005), and hematological manifestations of SLE (p = 0.02).
Periodical determination of β2M concentration in SLE patients may prove helpful in assessing the disease activity.
系统性红斑狼疮（SLE）的特点是病情活动期与缓解期交替出现。一部分患者患有疾病的慢性活动形式。目前正在寻找其活动的临床有用标志物。目前，有人提出β2-微球蛋白（β2M）可能有助于评估SLE的活动情况。
本文的目的是研究血清β2M浓度与SLE活动之间的关系。
研究组由69例SLE患者组成（62例女性和7例男性），年龄34.5±11岁（19 - 69岁）。肾衰竭和感染患者被排除在研究组之外。使用酶联免疫吸附测定（ELISA）检测法测量β2M的浓度。采用系统性红斑狼疮疾病活动指数2000（SLEDAI - 2K）评估SLE活动情况，并测量C3和C4补体成分、抗双链DNA抗体（抗dsDNA抗体）和β2M的水平。该研究还涵盖了β2M与SLE临床表现之间的关系。
研究发现β2M浓度与SLEDAI - 2K疾病活动指数（p < 0.05；r = 0.6）、抗dsDNA滴度（p < 0.05；r = 0.3）以及C4成分血清水平（p < 0.05；r = -0.3）之间存在统计学显著相关性。关节炎和/或肌炎患者（p = 0.005）、血管炎患者（p = 0.005）以及SLE血液学表现患者（p = 0.02）的β2M浓度显著更高。
定期测定SLE患者的β2M浓度可能有助于评估疾病活动情况。
