Internal Medicine, Rheumatology and Immunology, Faculty of Medicine, 2 Staff Member Buildings of Ain Shams University, Ramsis Street, Abbassya Square, El Al Waili/El-Abaseya, Post No: 11517, Cairo, Egypt.
Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Ramsis Street, Abbassya Square, Cairo, Egypt.
Rheumatol Int. 2023 Feb;43(2):323-333. doi: 10.1007/s00296-022-05221-1. Epub 2022 Oct 7.
A strong correlation between lupus nephritis (LN), disease activity, and serum beta 2-microglobulin (b2MG) was observed. The current study examines the correlation between serum b2MG and renal involvement, damage score, and disease activity in systemic lupus erythematosus (SLE) patients. One hundred SLE patients from Ain Shams University Hospital were enrolled and categorized into two groups. Group I had 40 patients with negative b2MG, while Group II had 60 patients with positive b2MG levels. Medical history, clinical examination, and assessing disease activity based on SLE disease activity index (SLEDAI-2 K), and damage score were recorded for all patients. Laboratory examinations, such as serum b2MG, complete blood count, blood urea nitrogen (BUN), serum creatinine, glomerular filtration rate (GFR), urine analysis, 24 h urinary protein excretion, Antinuclear antibodies (ANA), anti-dsDNA antibody, and serum complement (C3, C4). BUN, 24 h urinary protein, serum creatinine, active urinary sediment, SLEDAI score, and damage score were all elevated in group II compared to group I (p < 0.001). There is a positive correlation between serum b2MG and 24 h urinary protein, BUN, serum creatinine, disease activity, and damage score (p < 0.001), while it was negatively correlated with GFR, C3, and C4 (p < 0.001). Serum b2MG has proven to be a predictor of LN in SLE patients (Sensitivity 92.45%, Specificity 74.47%), also being a predictor of the activity of the disease as well as damage index (Sensitivity 96.67%, Specificity 85%) (Sensitivity 92.45%, Specificity 74.47%), respectively. Serum b2MG level can be used as a valuable predictor for LN, clinical disease activity, and damage score.
观察到狼疮肾炎 (LN)、疾病活动度和血清β2-微球蛋白 (b2MG) 之间存在很强的相关性。本研究旨在探讨系统性红斑狼疮 (SLE) 患者血清 b2MG 与肾脏受累、损伤评分和疾病活动度之间的相关性。研究纳入了来自艾因夏姆斯大学医院的 100 例 SLE 患者，并将其分为两组。第 I 组有 40 例患者血清 b2MG 阴性，第 II 组有 60 例患者血清 b2MG 水平阳性。所有患者均记录了病史、临床检查，并根据 SLE 疾病活动指数 (SLEDAI-2K) 和损伤评分评估疾病活动度。实验室检查包括血清 b2MG、全血细胞计数、血尿素氮 (BUN)、血清肌酐、肾小球滤过率 (GFR)、尿液分析、24 小时尿蛋白排泄、抗核抗体 (ANA)、抗双链 DNA 抗体和血清补体 (C3、C4)。与第 I 组相比，第 II 组的 BUN、24 小时尿蛋白、血清肌酐、活动尿沉渣、SLEDAI 评分和损伤评分均升高（p<0.001）。血清 b2MG 与 24 小时尿蛋白、BUN、血清肌酐、疾病活动度和损伤评分呈正相关（p<0.001），与 GFR、C3 和 C4 呈负相关（p<0.001）。血清 b2MG 已被证明是 SLE 患者 LN 的预测因子（敏感性 92.45%，特异性 74.47%），也是疾病活动度和损伤指数的预测因子（敏感性 96.67%，特异性 85%）。血清 b2MG 水平可作为 LN、临床疾病活动度和损伤评分的有价值预测因子。
