PEDEGO Research Unit, Medical Research Centre, University of Oulu; and Department of Otorhinolaryngology, Head and Neck Surgery, Oulu University Hospital, Finland.
PEDEGO Research Unit, Medical Research Centre, University of Oulu, Finland.
Clin Exp Rheumatol. 2018 Nov-Dec;36(6 Suppl 115):129-134. Epub 2018 Feb 27.
To compare the long-term morbidity of patients with periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome treated by tonsillectomy (TE) in childhood to that of matched controls.
We identified 132 PFAPA patients from the medical records treated by TE in 1987-2007 in Oulu University Hospital, Finland. Altogether 119 patients participated the follow-up study and 94 were clinically examined on average 9.0 years after TE. The controls consisted of 230 randomly selected age-, sex-, and birth place-matched individuals from the Population Register Center of Finland. The patients and controls completed a detailed questionnaire about their current health and the data were compared.
Self-estimated general health was good and growth was normal among PFAPA patients and controls at long-term follow-up. There were no between-group differences in the occurrence of autoimmune or other chronic diseases. Thirty percent of the PFAPA patients and 13% of the controls reported infections as causes of hospital visits during their lifetime (p<0.001). Usage of antibiotics during lifetime was reported by 99% of the PFAPA patients and by 88% of the controls (p= 0.009). Twelve percent of PFAPA patients and 0.4% of the controls reported oral thrush in their history (p=0.003).
The health of the PFAPA patients was as good as that of healthy matched controls. Autoimmune or other chronic diseases were not more prevalent among PFAPA patients treated with TE in childhood than among controls. Respiratory infections and oral thrush were more common among the PFAPA patients than controls.
比较经扁桃体切除术（TE）治疗的儿童期周期性发热、口疮性口炎、咽炎和淋巴结炎（PFAPA）综合征患者与匹配对照者的长期发病率。
我们从芬兰奥卢大学医院 1987 年至 2007 年的病历中确定了 132 例 PFAPA 患者，这些患者均接受 TE 治疗。共有 119 例患者参加了随访研究，94 例患者在 TE 后平均 9.0 年接受了临床检查。对照组由芬兰人口登记中心随机选择的 230 名年龄、性别和出生地匹配的个体组成。患者和对照组均完成了一份关于其当前健康状况的详细问卷，并对数据进行了比较。
PFAPA 患者和对照组在长期随访中自我评估的总体健康状况良好，生长发育正常。两组之间发生自身免疫性或其他慢性疾病的情况无差异。30%的 PFAPA 患者和 13%的对照组报告称，一生中因感染而住院（p<0.001）。PFAPA 患者中有 99%和对照组中有 88%报告一生中使用过抗生素（p=0.009）。PFAPA 患者中有 12%和对照组中有 0.4%报告有口腔鹅口疮病史（p=0.003）。
PFAPA 患者的健康状况与健康匹配对照组相当。与接受 TE 治疗的儿童期 PFAPA 患者相比，对照组中自身免疫性或其他慢性疾病的发病率并不更高。PFAPA 患者的呼吸道感染和口腔鹅口疮比对照组更常见。
