INSERM U1151-CNRS UMR 8253, Institut Necker Enfants-Malades (INEM), 70014 Paris, France; Université Paris Descartes-Sorbonne Paris Cité, 70006 Paris, France.
Dev Cell. 2018 Mar 12;44(5):537-539. doi: 10.1016/j.devcel.2018.02.019.
FOXO3a, a member of the Forkhead transcription factor family, has roles in apoptosis and autophagy. In this issue of Developmental Cell, Fitzwalter et al. (2018) describe how the blockade of FOXO3a turnover, which normally occurs through autophagy, sensitizes cancer cells to apoptosis through FOXO3a-mediated stimulation of pro-apoptotic PUMA/BBC3 expression.
叉头框转录因子家族的成员 FOXO3a 在细胞凋亡和自噬中发挥作用。在本期《发育细胞》中，Fitzwalter 等人（2018 年）描述了通过自噬正常发生的 FOXO3a 周转的阻断如何通过 FOXO3a 介导的促凋亡 PUMA/BBC3 表达的刺激使癌细胞对细胞凋亡敏感。
