Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.
Cancer Cell. 2018 Mar 12;33(3):347-354. doi: 10.1016/j.ccell.2018.02.001.
Metastases arising from tumors have the proclivity to colonize specific organs, suggesting that they must rewire their biology to meet the demands of the organ colonized, thus altering their primary properties. Each metastatic site presents distinct metabolic challenges to a colonizing cancer cell, ranging from fuel and oxygen availability to oxidative stress. Here, we discuss the organ-specific metabolic adaptations that cancer cells must undergo, which provide the ability to overcome the unique barriers to colonization in foreign tissues and establish the metastatic tissue tropism phenotype.
肿瘤转移具有在特定器官定植的倾向，这表明它们必须重新调整生物学特性以适应定植器官的需求，从而改变其原发特性。每个转移部位都会给定植的癌细胞带来独特的代谢挑战，从燃料和氧气的供应到氧化应激。在这里，我们讨论了癌细胞必须经历的器官特异性代谢适应，这使它们能够克服在异质组织中定植的独特障碍，并建立转移组织嗜性表型。
