Skillman C A, Clark K E
Biol Neonate. 1987;51(4):217-23. doi: 10.1159/000242656.
Fetal beta-endorphin release has been associated with fetal hypoxia. The purpose of this study was to assess the degree of uterine blood flow reduction needed to elicit fetal beta-endorphin release in the sheep since there is a large reserve of oxygen supply to the fetus. Uterine blood flow was reduced by 26 +/- 2, 46 +/- 3 and 66 +/- 2%, producing fetal oxygen content concentrations of 5.7 +/- 0.6, 4.4 +/- 0.7 and 2.6 +/- 0.3 ml/dl, respectively. Although fetal oxygen concentrations were significantly decreased in the groups with a reduction in uterine blood flow of 46 and 66%, beta-endorphin was elevated only in the latter group. It is speculated that fetal beta-endorphin is released at a level of hypoxia which leads to a decrease in fetal oxygen consumption. A reduction in uterine blood flow of 66% appears to produce a stressful environment for the fetus as measured by fetal plasma beta-endorphin levels.
胎儿β-内啡肽的释放与胎儿缺氧有关。本研究的目的是评估在绵羊中引发胎儿β-内啡肽释放所需的子宫血流减少程度，因为胎儿有大量的氧气供应储备。子宫血流分别减少了26±2%、46±3%和66±2%，胎儿氧含量浓度分别为5.7±0.6、4.4±0.7和2.6±0.3 ml/dl。虽然子宫血流减少46%和66%的组中胎儿氧浓度显著降低，但β-内啡肽仅在后者组中升高。据推测，胎儿β-内啡肽在导致胎儿氧消耗减少的缺氧水平时释放。从胎儿血浆β-内啡肽水平测量来看，子宫血流减少66%似乎为胎儿产生了一个应激环境。
