Department of Medical Biology, Ataturk University, Erzurum, Turkey.
Department of Dermatology, Ataturk University, Erzurum, Turkey.
Med Sci Monit. 2018 Mar 13;24:1511-1516. doi: 10.12659/msm.907918.
BACKGROUND To investigate the gene expression levels of interleukin 10 (IL10), IL18, interferon gamma (IFNG), IFN-gamma receptor (IFNGR), C-reactive protein (CRP), and heat shock protein 70 (HSP70) in patients with active Behçet's uveitis. MATERIAL AND METHODS Forty patients with Behçet's disease diagnosed according to the International Study Group criteria and 30 healthy individuals were included in the study. IL10, IL18, IFNG, IFNGR, CRP, and HSP70 gene expression levels were compared. RESULTS Expression levels of IL18, IFNG, IFNGR, and CRP were significantly higher in patients with active Behçet's uveitis than in control subjects (P<0.01 for all), whereas no significant differences were found in IL10 and HSP70 gene expression levels (P>0.01 for both). CONCLUSIONS IL18, IFNG, IFNGR, and CRP gene expression is significantly increased in active Behçet's uveitis. There was no significant difference between active Behçet's uveitis patients and controls in terms of IL10 and HSP70 gene expression levels. We conclude that drugs prescribed to Behçet's patients with active uveitis downregulate gene expression.
研究活动期贝赫切特葡萄膜炎患者白细胞介素 10（IL10）、白细胞介素 18（IL18）、干扰素 γ（IFNG）、IFN-γ 受体（IFNGR）、C 反应蛋白（CRP）和热休克蛋白 70（HSP70）的基因表达水平。
本研究纳入了 40 例根据国际研究组标准诊断的贝赫切特病患者和 30 名健康对照者。比较了 IL10、IL18、IFNG、IFNGR、CRP 和 HSP70 基因的表达水平。
活动期贝赫切特葡萄膜炎患者的 IL18、IFNG、IFNGR 和 CRP 基因表达水平明显高于对照组（均 P<0.01），而 IL10 和 HSP70 基因表达水平无显著差异（均 P>0.01）。
活动期贝赫切特葡萄膜炎患者的 IL18、IFNG、IFNGR 和 CRP 基因表达明显增加。活动期贝赫切特葡萄膜炎患者和对照组的 IL10 和 HSP70 基因表达水平无显著差异。我们的结论是，用于治疗活动期贝赫切特葡萄膜炎患者的药物可下调基因表达。
