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蒽环类抗生素米托蒽醌的破坏吸附和光催化降解。

Anthracycline antibiotics derivate mitoxantrone-Destructive sorption and photocatalytic degradation.

机构信息

Department of Oncology, 1st Faculty of Medicine, Charles University in Prague, Czech Republic.

Department of Material Chemistry, Institute of Inorganic Chemistry ASCR, Husinec-Rez, Czech Republic.

出版信息

PLoS One. 2018 Mar 13;13(3):e0193116. doi: 10.1371/journal.pone.0193116. eCollection 2018.

DOI:10.1371/journal.pone.0193116
PMID:29534071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5849306/
Abstract

Nanostructured titanium(IV) oxide was used for the destructive adsorption and photocatalytic degradation of mitoxantrone (MTX), a cytostatic drug from the group of anthracycline antibiotics. During adsorption on a titania dioxide surface, four degradation products of MTX, mitoxantrone dicarboxylic acid, 1,4-dihydroxy-5-((2-((2-hydroxyethyl)amino)ethyl)amino)-8-((2-(methylamino)ethyl)amino)anthracene-9,10-dione, 1,4-dihydroxy-5,8-diiminoanthracene-9,10(5H,8H)-dione and 1,4-dihydroxy-5-imino-8-(methyleneamino)anthracene-9,10(5H,8H)-dione, were identified. In the case of photocatalytic degradation, only one degradation product after 15 min at m/z 472 was identified. This degradation product corresponded to mitoxantrone dicarboxylic acid, and complete mineralization was attained in one hour. Destructive adsorbent manganese(IV) oxide, MnO2, was used only for the destructive adsorption of MTX. Destructive adsorption occurred only for one degradation product, mitoxantrone dicarboxylic acid, against anatase TiO2.

摘要

纳米结构的二氧化钛被用于米托蒽醌（MTX）的破坏性吸附和光催化降解，米托蒽醌是一种来自蒽环类抗生素的细胞抑制剂药物。在二氧化钛表面吸附时，MTX 的四个降解产物，米托蒽醌二羧酸、1,4-二羟基-5-((2-((2-羟乙基)氨基)乙基)氨基)-8-((2-(甲基氨基)乙基)氨基)蒽-9,10-二酮、1,4-二羟基-5,8-二亚氨基蒽-9,10(5H,8H)-二酮和 1,4-二羟基-5-亚氨基-8-(亚甲基氨基)蒽-9,10(5H,8H)-二酮被鉴定出来。在光催化降解的情况下，在 m/z 472 处仅在 15 分钟后鉴定出一种降解产物。该降解产物对应于米托蒽醌二羧酸，并且在一小时内实现了完全矿化。破坏性吸附剂二氧化锰（MnO2）仅用于 MTX 的破坏性吸附。破坏性吸附仅针对米托蒽醌二羧酸发生在锐钛矿 TiO2 上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bbf/5849306/9741c6763830/pone.0193116.g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bbf/5849306/9741c6763830/pone.0193116.g008.jpg

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本文引用的文献

1
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Photochem Photobiol. 2013 Sep-Oct;89(5):1038-46. doi: 10.1111/php.12139. Epub 2013 Aug 26.
2
Hydrogen peroxide route to Sn-doped titania photocatalysts.通过过氧化氢法制备锡掺杂二氧化钛光催化剂。
Chem Cent J. 2012 Oct 5;6(1):113. doi: 10.1186/1752-153X-6-113.
3
Oxidative metabolism of the anti-cancer agent mitoxantrone by horseradish, lacto-and lignin peroxidase.
从水生环境中去除蒽环类细胞抑制剂：纳米晶二氧化钛与去污剂的比较。
PLoS One. 2019 Oct 11;14(10):e0223117. doi: 10.1371/journal.pone.0223117. eCollection 2019.
辣根过氧化物酶、乳过氧化物酶和木质素过氧化物酶对抗癌药物米托蒽醌的氧化代谢。
Biochimie. 2011 Feb;93(2):217-26. doi: 10.1016/j.biochi.2010.09.015. Epub 2010 Sep 29.
4
Photocatalytic activity of boron-modified titania under UV and visible-light illumination.硼改性二氧化钛在紫外光和可见光照射下的光催化活性。
ACS Appl Mater Interfaces. 2010 Feb;2(2):575-80. doi: 10.1021/am9007598.
5
A new method for quantifying the intensity of the C=C band of dimethacrylate dental monomers in their FTIR and Raman spectra.一种用于量化二甲基丙烯酸酯类牙科单体在其傅里叶变换红外光谱和拉曼光谱中 C=C 带强度的新方法。
Biomaterials. 2005 Nov;26(33):6440-8. doi: 10.1016/j.biomaterials.2005.04.039.
6
FTIR studies of phytochrome photoreactions reveal the C=O bands of the chromophore: consequences for its protonation states, conformation, and protein interaction.
Biochemistry. 2001 Dec 11;40(49):14952-9. doi: 10.1021/bi0156916.
7
Reactions of VX, GB, GD, and HD with nanosize Al(2)O(3). Formation of aluminophosphonates.
J Am Chem Soc. 2001 Feb 28;123(8):1636-44. doi: 10.1021/ja003518b.
8
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Eur J Clin Pharmacol. 1998 Mar;54(1):83-9. doi: 10.1007/s002280050425.
9
Thermal denaturation of globular proteins. Fourier transform-infrared studies of the amide III spectral region.球状蛋白质的热变性。酰胺III光谱区域的傅里叶变换红外研究。
Biophys J. 1987 Jul;52(1):69-74. doi: 10.1016/S0006-3495(87)83189-2.
10
Pharmacokinetics and metabolism of mitoxantrone. A review.
Clin Pharmacokinet. 1990 May;18(5):365-80. doi: 10.2165/00003088-199018050-00003.