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从水生环境中去除蒽环类细胞抑制剂：纳米晶二氧化钛与去污剂的比较。

Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents.

机构信息

Institute of Inorganic Chemistry of the Czech Academy of Sciences, Řež, Czech Republic.

1st Faculty of Medicine, Charles University in Prague, Ovocný trh, Czech Republic.

出版信息

PLoS One. 2019 Oct 11;14(10):e0223117. doi: 10.1371/journal.pone.0223117. eCollection 2019.

DOI:10.1371/journal.pone.0223117
PMID:31603899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6788709/
Abstract

Anthracyclines are a class of pharmaceuticals used in cancer treatment have the potential to negatively impact the environment. To study the possibilities of anthracyclines (represented by pirarubicin and valrubicin) removal, chemical inactivation using NaOH (0.01 M) and NaClO (5%) as decontamination agents and adsorption to powdered nanocrystalline titanium dioxide (TiO2) were compared. The titanium dioxide (TiO2) nanoparticles were prepared via homogeneous precipitation of an aqueous solution of titanium (IV) oxy-sulfate (TiOSO4) at different amount (5-120 g) with urea. The as-prepared TiO2 samples were characterized by XRD, HRSEM and nitrogen physisorption. The adsorption process of anthracycline cytostatics was determined followed by high-performance liquid chromatography coupled with mass spectrometry (LC-MS) and an in-situ Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) technique. It was found that NaClO decomposes anthracyclines to form various transformation products (TPs). No TPs were identified after the reaction of valrubicin with a NaOH solution as well as in the presence of TiO2 nanoparticles. The best degree of removal, 100% of pirarubicin and 85% of valrubicin, has been achieved in a sample with 120 grams of TiOSO4 (TIT120) and TiO2 with 60 grams (TIT60), respectively.

摘要

蒽环类药物是一类用于癌症治疗的药物，有可能对环境造成负面影响。为了研究蒽环类药物（以吡柔比星和表柔比星为代表）的去除可能性，比较了使用 0.01 M NaOH 和 5% NaClO 进行化学失活以及吸附到纳米晶粉末二氧化钛（TiO2）上的方法。TiO2 纳米粒子通过在不同量（5-120 g）的尿素存在下，均匀沉淀钛（IV）氧硫酸盐（TiOSO4）的水溶液来制备。通过 XRD、高分辨率扫描电子显微镜（HRSEM）和氮气物理吸附对所制备的 TiO2 样品进行了表征。通过高效液相色谱-质谱联用（LC-MS）和原位漫反射红外傅里叶变换光谱（DRIFTS）技术确定了蒽环类细胞抑制剂的吸附过程。结果发现，NaClO 将蒽环类药物分解为各种转化产物（TPs）。在 valrubicin 与 NaOH 溶液反应以及存在 TiO2 纳米粒子的情况下，均未鉴定出 TPs。在 TiOSO4 用量为 120 克（TIT120）和 TiO2 用量为 60 克（TIT60）的样品中，分别实现了 100%的 pirarubicin 和 85%的 valrubicin 的最佳去除程度。

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