与恩曲他滨/替诺福韦用于HIV暴露前预防起始治疗相关的急性三叉神经痛
Acute Trigeminal Neuralgia Associated with Initiation of Emtricitabine/Tenofovir for HIV Pre-Exposure Prophylaxis.
作者信息
Van Slyke Loraine, Scott Mia
机构信息
1 APEX Research/Family Medicine, Denver, CO, USA.
出版信息
J Int Assoc Provid AIDS Care. 2018 Jan-Dec;17:2325958218760846. doi: 10.1177/2325958218760846.
Abstract
HIV pre-exposure prophylaxis (PrEP) with emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF) fixed-dose combination (FTC/TDF) is undergoing rapid scale-up in the United States. While FTC/TDF is typically well tolerated, to our knowledge, cranial nerve pathology associated with FTC/TDF has not been previously described. We report the case of a 35-year-old patient who began FTC/TDF PrEP and developed acute trigeminal neuralgia. The neurologic symptoms resolved after treatment discontinuation and recurred upon rechallenge, resulting in permanent discontinuation of PrEP treatment.
摘要
在美国，恩曲他滨（FTC）和替诺福韦酯（TDF）的固定剂量组合（FTC/TDF）用于艾滋病病毒暴露前预防（PrEP）正在迅速扩大规模。虽然FTC/TDF通常耐受性良好，但据我们所知，此前尚未描述过与FTC/TDF相关的颅神经病变。我们报告了一名35岁患者的病例，该患者开始使用FTC/TDF进行PrEP并出现急性三叉神经痛。停药后神经症状缓解，再次用药时复发，导致PrEP治疗永久停药。
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