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恶性淋巴瘤第 14 次国际会议(ICML)临床试验未来设计闭会专题研讨会报告。

Report of the 14th International Conference on Malignant Lymphoma (ICML) Closed Workshop on Future Design of Clinical Trials in Lymphomas.

机构信息

Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

出版信息

Clin Cancer Res. 2018 Jul 1;24(13):2993-2998. doi: 10.1158/1078-0432.CCR-17-3021. Epub 2018 Mar 13.

Abstract

The 14th ICML held in Lugano in June 2017 was preceded by a closed workshop (organized in collaboration with the American Association for Cancer Research and the European School of Oncology) where experts in preclinical and clinical research in lymphomas met to discuss the current drug development landscape focusing on critical open questions that need to be addressed in the future to permit a more efficient drug development paradigm in lymphoma. Topics discussed included both preclinical models that can be used to test new drugs and drug combinations, as well as the optimal design of clinical trials and the endpoints that should be used to facilitate accelerated progress. This report represents a summary of the workshop. .

摘要

2017 年 6 月在卢加诺举行的第 14 届 ICML 会议之前,举行了一次闭门研讨会(与美国癌症研究协会和欧洲肿瘤学院合作组织),临床前和临床淋巴瘤研究专家聚集在一起,讨论当前药物开发的现状,重点讨论了未来需要解决的关键开放性问题,以促进淋巴瘤药物开发的范式更有效。讨论的主题包括可用于测试新药和药物组合的临床前模型,以及临床试验的最佳设计和应该用于促进加速进展的终点。本报告是研讨会的总结。

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