Department of NeurosurgeryHospital Pablo Tobon Uribe and Clinica Medellin, Medellin, Colombia
Division of PathologyDepartment of Laboratory Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Endocr Relat Cancer. 2018 Aug;25(8):T159-T169. doi: 10.1530/ERC-18-0015. Epub 2018 Mar 13.
Temozolomide is an alkylating chemotherapeutic agent used in malignant neuroendocrine neoplasia, melanoma, brain metastases and an essential component of adjuvant therapy in the treatment of glioblastoma multiforme and anaplastic astrocytoma. Since 2006, it has been used for the treatment of pituitary carcinomas and aggressive pituitary adenomas. Here, we discuss the current indications and results of temozolomide therapy in pituitary tumors, as well as frequently asked questions regarding temozolomide treatment, duration of therapy, dosage, tumor recurrence and resistance.
替莫唑胺是一种烷化化疗药物，用于恶性神经内分泌肿瘤、黑色素瘤、脑转移瘤，也是多形性胶质母细胞瘤和间变性星形细胞瘤辅助治疗的重要组成部分。自 2006 年以来，它一直用于治疗垂体癌和侵袭性垂体腺瘤。在这里，我们讨论了替莫唑胺治疗垂体肿瘤的当前适应证和结果，以及关于替莫唑胺治疗、治疗持续时间、剂量、肿瘤复发和耐药性的常见问题。
