Tang Liang, Li Jianming, Bao Meihua, Xiang Ju, Chen Yiwei, Wang Yan
Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, People's Republic of China.
Department of Human Anatomy, School of Basic Medical Science, Changsha Medical University, Changsha, People's Republic of China.
Onco Targets Ther. 2018 Mar 1;11:1055-1066. doi: 10.2147/OTT.S149428. eCollection 2018.
The estrogen receptor (ER) and the human epidermal growth factor receptor 2 (HER2) each play an important role in female cancers. This study aimed to investigate the genetic association between three common single nucleotide polymorphisms (SNPs) and the risk of ovarian cancer. The SNPs investigated in this study were ESR2 rs1271572 and rs3020450 and HER2 rs1801200.
In this study, databases were electronically searched in a meta-analysis. Databases used were PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang and Cochrane library. Case-control studies on the association between ESR2 and HER2 polymorphisms were selected according to inclusion and exclusion standard. Articles were evaluated for quality, and data were extracted.
A total of 13 articles with 5,461 cases and 7,603 controls were included in this meta-analysis. The recessive model of ESR2 rs1271572 was shown to be significantly associated with the risk of ovarian cancer ( = 0.008, odds ratio [OR] [95% confidence interval {CI}] = 1.13 [1.03, 1.24]), and this significant association still existed in a subgroup analysis stratified by ethnicity (Asian: = 0.04, OR [95% CI] = 1.92 [1.04, 3.56]; Caucasian: = 0.02, OR [95% CI] = 1.12 [1.02, 1.23]). In addition, the distribution of the dominant model of ESR2 rs3020450 was significantly different in the total group ( = 0.02, OR [95% CI] = 0.71 [0.53, 0.95]) and the Caucasian subgroup ( = 0.02, OR [95% CI] = 0.67 [0.48, 0.94]). Furthermore, no significant association between allelic, dominant, codominant and recessive models of HER2 rs1801200 (V655I) and ovarian cancer was found ( > 0.05).
The recessive model of ESR2 rs1271572 and the dominant model of ESR2 rs3020450 might be susceptible factors for ovarian cancer.
雌激素受体（ER）和人表皮生长因子受体2（HER2）在女性癌症中均发挥重要作用。本研究旨在调查三种常见单核苷酸多态性（SNP）与卵巢癌风险之间的遗传关联。本研究中调查的SNP为ESR2 rs1271572和rs3020450以及HER2 rs1801200。
在本研究中，通过荟萃分析对数据库进行电子检索。使用的数据库有PubMed、Embase、中国知网（CNKI）、万方和考克兰图书馆。根据纳入和排除标准选择关于ESR2和HER2多态性关联的病例对照研究。对文章进行质量评估，并提取数据。
本荟萃分析共纳入13篇文章，包含5461例病例和7603例对照。ESR2 rs1271572的隐性模型显示与卵巢癌风险显著相关（P = 0.008，比值比[OR][95%置信区间{CI}] = 1.13[1.03, 1.24]），并且在按种族分层的亚组分析中这种显著关联仍然存在（亚洲人：P = 0.04，OR[95% CI] = 1.92[1.04, 3.56]；高加索人：P = 0.02，OR[95% CI] = 1.12[1.02, 1.23]）。此外，ESR2 rs3020450的显性模型在总体组（P = 0.02，OR[95% CI] = 0.71[0.53, 0.95]）和高加索亚组（P = 0.02，OR[95% CI] = 0.67[0.48, 0.94]）中的分布存在显著差异。此外，未发现HER2 rs1801200（V655I）的等位基因、显性、共显性和隐性模型与卵巢癌之间存在显著关联（P > 0.05）。
ESR2 rs1271572的隐性模型和ESR2 rs3020450的显性模型可能是卵巢癌易患因素。
