Department of Basic Medicine, Zhangzhou Health Vocational College, Zhangzhou, 363000 Fujian Province, China.
Department of Orthopaedic Surgery, Dongnan Hospital of Xiamen University, School of Medicine, Xiamen University, Zhangzhou, 363000 Fujian Province, China.
J Clin Densitom. 2022 Oct-Dec;25(4):699-711. doi: 10.1016/j.jocd.2022.08.007. Epub 2022 Aug 23.
Recently, the roles of ESR1 and ESR2 polymorphisms in osteoporosis have been extensively reported, with conflicting findings. Therefore, we performed this present study to evaluate the potential associations between ESR1 and ESR2 polymorphisms and osteoporosis risk.
All included literatures published up to April 2021 were identified by searching Pubmed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated the associations using a fixed or random effects model.
36 observational studies involving five gene polymorphisms (ESR1 PvuII, ESR1 XbaI, ESR1 G2014A, ESR2 AluI and ESR2 RsaI) covering 12507 cases and 18487 controls were included. The results of our meta-analysis demonstrated the variant A allele of ESR2 RsaI polymorphism might play a remarkable protective role in developing osteoporosis under all genetic models. However, no associations were observed between ESR1 PvuII, ESR1 XbaI, ESR1 G2014A and ESR2 AluI polymorphisms with the risk of osteoporosis under all genetic models.
Our meta-analysis suggests that genetic polymorphism in ESR2 RsaI may lead to decreased risk for osteoporosis. Further larger studies are needed to confirm this conclusion.
最近，ESR1 和 ESR2 多态性在骨质疏松症中的作用得到了广泛的报道，但研究结果存在矛盾。因此，我们进行了本研究，以评估 ESR1 和 ESR2 多态性与骨质疏松症风险之间的潜在关联。
通过检索 Pubmed、Embase、Web of Science、Cochrane Library、中国知网（CNKI）和万方数据库，确定截至 2021 年 4 月发表的所有纳入文献。使用固定或随机效应模型计算关联的合并优势比（OR）和 95%置信区间（CI）。
纳入了 36 项观察性研究，涉及五个基因多态性（ESR1 PvuII、ESR1 XbaI、ESR1 G2014A、ESR2 AluI 和 ESR2 RsaI），共涵盖 12507 例病例和 18487 例对照。荟萃分析结果表明，ESR2 RsaI 多态性的变异 A 等位基因在所有遗传模型下可能对骨质疏松症的发生具有显著的保护作用。然而，在所有遗传模型下，ESR1 PvuII、ESR1 XbaI、ESR1 G2014A 和 ESR2 AluI 多态性与骨质疏松症风险之间均无关联。
本荟萃分析表明，ESR2 RsaI 基因多态性可能导致骨质疏松症风险降低。需要进一步开展更大规模的研究来证实这一结论。
