Department of Obstetrics and Gynecology, University Medical Center Regensburg, Regensburg, Germany.
Gynecol Oncol. 2012 Dec;127(3):673-6. doi: 10.1016/j.ygyno.2012.09.006. Epub 2012 Sep 11.
Estrogen receptor β is expressed in normal and neoplastic ovarian and endometrial tissues. Recent studies indicate that levels of this receptor decline in ovarian tumorigenesis, like in breast or prostate cancer. Furthermore, ERβ expression has been associated with good prognosis in ovarian cancer. In contrast, previous studies on the role of this receptor in endometrial cancer suggested that ERβ might play different roles in the carcinogenesis of the ovary and endometrium. Besides its possible role as a prognostic factor, ERβ might be a potential target for the treatment of ovarian and endometrial cancer.
雌激素受体 β 在正常和肿瘤性卵巢和子宫内膜组织中表达。最近的研究表明，这种受体在卵巢肿瘤发生过程中的水平下降，就像在乳腺癌或前列腺癌中一样。此外，ERβ 表达与卵巢癌的良好预后相关。相比之下，先前关于该受体在子宫内膜癌中的作用的研究表明，ERβ 可能在卵巢和子宫内膜癌的发生中发挥不同的作用。除了作为预后因素的可能作用外，ERβ 可能是治疗卵巢和子宫内膜癌的潜在靶点。
