Moser Katharina, Mitze Stefanie, Teske Erik, von Bomhard Wolf, Stockhaus Christian
Tierarztl Prax Ausg K Kleintiere Heimtiere. 2018 Feb;46(1):15-20. doi: 10.15654/TPK-170445. Epub 2018 Feb 21.
The objective of this study was to correlate clinical signs and diagnostic parameters with duodenal inflammatory and architectural changes in dogs with lymphocytic-plasmacytic enteropathy.
In a retrospective study dogs presented between 2003 and 2014 with chronic gastrointestinal signs (duration > 3 weeks) and histologic evidence of intestinal lymphocytic-plasmacytic inflammation were evaluated. Clinical signs, serum albumin, cobalamin and folic acid concentrations were recorded and a sonographic, endoscopic, histologic and cytological inflammatory score was determined. Furthermore, the presence of lacteal dilation, villus stunting, crypt lesions, epithelial integrity and increased intraepithelial lympho cytes was evaluated.
A total of 270 dogs were retrospectively evaluated. No significant correlation was found between clinical signs and sonographic, endoscopic or duodenal inflammatory score. Dogs with histological signs of lacteal dilation (p = 0.001) and increased intraepithelial lymphocytes (p = 0.005) had significantly higher clinical scores compared to dogs without these changes. No correlation was found between clinical score and villous stunting or crypt lesions. Hypoalbuminemia and hypocobalaminemia correlated significantly with lacteal dilation (p = 0.001, p = 0.009) and increased intraepithelial lymphocytes (p = 0.036, p = 0.018).
Some clinical and diagnostic parameter correlate with histopathologic features whereas others do not. Morphological features seem to be more important than the intensity of the duodenal inflammation in the assessment of the disease.
本研究的目的是将临床体征和诊断参数与淋巴细胞 - 浆细胞性肠病犬的十二指肠炎症及结构变化相关联。
在一项回顾性研究中，对2003年至2014年间出现慢性胃肠道体征（持续时间> 3周）且有肠道淋巴细胞 - 浆细胞性炎症组织学证据的犬进行评估。记录临床体征、血清白蛋白、钴胺素和叶酸浓度，并确定超声、内镜、组织学和细胞学炎症评分。此外，评估淋巴管扩张、绒毛发育不良、隐窝病变、上皮完整性和上皮内淋巴细胞增多的情况。
总共对270只犬进行了回顾性评估。未发现临床体征与超声、内镜或十二指肠炎症评分之间存在显著相关性。与没有这些变化的犬相比，有淋巴管扩张组织学体征（p = 0.001）和上皮内淋巴细胞增多（p = 0.005）的犬临床评分显著更高。未发现临床评分与绒毛发育不良或隐窝病变之间存在相关性。低白蛋白血症和低钴胺素血症与淋巴管扩张（p = 0.001，p = 0.009）和上皮内淋巴细胞增多（p = 0.036，p = 0.018）显著相关。
一些临床和诊断参数与组织病理学特征相关，而其他参数则不然。在评估该疾病时，形态学特征似乎比十二指肠炎症的强度更重要。
