来自卷枝毛壳菌的高光敏性聚硫桥切托米辛类似物。
Highly Photosensitive Poly-Sulfur-Bridged Chetomin Analogues from Chaetomium cochliodes.
机构信息
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100193 , P.R. China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , P.R. China.
出版信息
Org Lett. 2018 Apr 6;20(7):1806-1809. doi: 10.1021/acs.orglett.8b00304. Epub 2018 Mar 14.
The highly photosensitive characteristic of poly-sulfide chetomins was first unveiled, and four new unstable analogues, chetomins A-D (1-4), with significant cytotoxicity were successfully purified in darkness. The visible-light-induced desulfurization and intermolecular disproportionation were revealed to initiate the interconversion of chetomin analogues, which explained the long-recognized puzzle of rarity and instability of chetomin analogues.
聚多硫化物 chetomins 的高光敏特性首次被揭示，并且在黑暗中成功地分离出四种具有显著细胞毒性的新型不稳定类似物 chetomins A-D（1-4）。可见光诱导的脱硫和分子间歧化被揭示为 chetomin 类似物相互转化的起始步骤，这解释了 chetomin 类似物稀有且不稳定这一长期存在的难题。
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