Fujimoto Haruhiro, Sumino Megumi, Okuyama Emi, Ishibashi Masami
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
J Nat Prod. 2004 Jan;67(1):98-102. doi: 10.1021/np0302201.
A screening study focusing on immunomodulatory activity of the EtOAc extract of an Ascomycete, Chaetomium seminudum, has afforded a known epipolythiodioxopiperazine, chetomin (1), together with three new chetomin-related metabolites named chetoseminudins A (2), B (3), and C (4). Among these four metabolites, 1 and 2 have been deduced as the immunosuppressive features of this fungus.
一项针对子囊菌半裸毛壳菌乙酸乙酯提取物免疫调节活性的筛选研究，得到了一种已知的表聚硫二氧哌嗪类化合物——切托明（1），以及三种新的与切托明相关的代谢产物，分别命名为切托半裸菌素A（2）、B（3）和C（4）。在这四种代谢产物中，1和2已被推断为该真菌的免疫抑制特性成分。
