State Key Laboratory of Respiratory Disease , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.
University of Chinese Academy of Sciences , No. 19(A) Yuquan Road , Shijingshan District , Beijing 100049 , China.
Org Lett. 2018 Apr 6;20(7):1837-1840. doi: 10.1021/acs.orglett.8b00348. Epub 2018 Mar 14.
A highly efficient synthesis of planar chiral pyrido[3,4- b] ferrocenes by a palladium-catalyzed enantioselective isocyanide insertion/desymmetric C(sp)-H bond activation reaction was developed. Various planar chiral pyridoferrocenes were obtained in high yields with good to excellent enantioselectivity under mild conditions (up to 99% yield, 99% ee), enabled by a unique SPINOL-derived phosphoramidite ligand.
通过钯催化的对映选择性异氰化物插入/去对称 C(sp)-H 键活化反应，高效合成了平面手性吡啶并[3,4-b]二茂铁。通过使用独特的 SPINOL 衍生的磷酰胺配体，在温和条件下（高达 99%的收率，99%的对映选择性），以高收率和优异的对映选择性得到了各种平面手性吡啶并二茂铁。
