Laboratory of Applied and Exercise Endocrinology, Pilgram Marpeck School of STEM, Truett McConnell University, Cleveland, GA.
Med Sci Sports Exerc. 2018 Aug;50(8):1588-1595. doi: 10.1249/MSS.0000000000001604.
The biological mechanisms regulating physical activity patterns appear to be linked to the sex hormones. Elucidation of these regulatory mechanisms may enhance individual physical activity patterns producing positive gains in health.
The purpose of this study was to evaluate the prolonged effects of estrogen on wheel running distance, duration, and speed in orchidectomized mice.
The physical activity patterns of 9-wk-old C57BL/6j male mice (n = 28) were observed. Wheel running distance, duration, and speed were assessed under physiological conditions for 7 d. Next, physical activity patterns were evaluated after bilateral orchidectomy (n = 14) or sham orchidectomy (n = 14) for an additional 7 d. Orchidectomized mice were provided estrogen containing capsules for three additional weeks; control mice were provided estrogen-free capsules. Wheel running distance, duration, and speed were analyzed by three two-way (treatment group-phase of study) analysis of variance tests.
Wheel running speed was unaffected by sex hormone status. Distance (mean ± SD = 6.74 ± 2.13 km at baseline) decreased significantly after orchidectomy (2.27 ± 1.55 km) and remained low after initial estrogen treatment (3.04 ± 1.05 km). Prolonged estrogen exposure sustained a significant elevation of daily distance (4.47 ± 1.87 km). Prolonged estrogen exposure recovered and significantly sustained wheel running duration (baseline, 248 ± 60 min; postorchidectomy, 102 ± 53 min; prolonged exposure, 170 ± 63 min).
Wheel running behavior was reduced significantly after orchidectomy and remained low after initial treatment with estrogens, but recovered to near control levels after 2 wk of exposure to estrogens. The estrogenic mechanism regulating wheel running behavior in male mice appears to induce an extensive but slow acting biological mechanism. Understanding the biological drive behind this mechanism may aid in developing useful therapeutic strategies to combat health issues related to physical inactivity.
调节身体活动模式的生物学机制似乎与性激素有关。阐明这些调节机制可以增强个体的身体活动模式，对健康产生积极的影响。
本研究的目的是评估雌激素对去势小鼠轮跑距离、时间和速度的长期影响。
观察 9 周龄 C57BL/6j 雄性小鼠（n=28）的身体活动模式。在生理条件下评估轮跑距离、时间和速度，持续 7 天。然后，对双侧去势（n=14）或假去势（n=14）的小鼠进行另外 7 天的评估。去势小鼠给予含有雌激素的胶囊 3 周；对照小鼠给予不含雌激素的胶囊。通过三个两因素（治疗组-研究阶段）方差分析测试分析轮跑距离、时间和速度。
轮跑速度不受性激素状态的影响。距离（平均±SD=6.74±2.13km，基线）在去势后显著下降（2.27±1.55km），并且在初始雌激素治疗后仍然较低（3.04±1.05km）。长期雌激素暴露维持了每日距离的显著升高（4.47±1.87km）。长期雌激素暴露恢复并显著维持轮跑时间（基线，248±60min；去势后，102±53min；长期暴露，170±63min）。
去势后轮跑行为显著减少，初始雌激素治疗后仍然较低，但暴露于雌激素 2 周后恢复到接近对照水平。调节雄性小鼠轮跑行为的雌激素机制似乎诱导了一个广泛但作用缓慢的生物学机制。了解这种机制背后的生物学驱动力可能有助于开发有用的治疗策略，以应对与身体活动不足相关的健康问题。
