Lv Chunjiang, Zhang Yongsheng, Shen Lili
Int Arch Allergy Immunol. 2018;175(4):231-236. doi: 10.1159/000486959. Epub 2018 Mar 14.
Resveratrol is a natural, nonflavonoid polyphenol, exerting anti-inflammatory activity. It has been reported that resveratrol, together with carboxymethyl-β-glucan, can reduce nasal symptoms in children with allergic rhinitis (AR). In this study, the effect of resveratrol on nasal symptoms in adults with AR was investigated.
We conducted a placebo-controlled, double-blinded study. One hundred and fifty-one adults (aged 18-60 years) with severe persistent AR were divided into a placebo-treated group (n = 50), a positive control budesonide-treated group (n = 50), and a resveratrol-treated group (n = 51). They were then treated with 2 sprays (100 µL/spray) in each nostril 3 times/day for 1 month. Nasal symptoms including obstruction, itching, sneezing, and rhinorrhea, and the levels of IgE, IL-4, TNF-α, and eosinophils in the blood were assessed at baseline and after treatment.
Adults treated with resveratrol or budesonide achieved a significant reduction in nasal symptoms compared to the placebo-treated group. The resveratrol treatment significantly decreased the IgE, IL-4, TNF-α, and eosinophil levels in the blood. In addition, the resveratrol treatment was found to improve the quality of life of adults with AR.
Our preliminary study showed that intranasal resveratrol is capable of significantly improving nasal symptoms in adults with AR.
白藜芦醇是一种天然的非黄酮类多酚，具有抗炎活性。据报道，白藜芦醇与羧甲基-β-葡聚糖一起可减轻过敏性鼻炎（AR）患儿的鼻部症状。在本研究中，我们调查了白藜芦醇对AR成年患者鼻部症状的影响。
我们进行了一项安慰剂对照的双盲研究。151名重度持续性AR成年患者（年龄18 - 60岁）被分为安慰剂治疗组（n = 50）、阳性对照布地奈德治疗组（n = 50）和白藜芦醇治疗组（n = 51）。然后他们每天在每个鼻孔喷2次（100 μL/次），共3次，持续1个月。在基线和治疗后评估鼻部症状，包括鼻塞、瘙痒、打喷嚏和流涕，以及血液中IgE、IL - 4、TNF - α和嗜酸性粒细胞水平。
与安慰剂治疗组相比，接受白藜芦醇或布地奈德治疗的成年患者鼻部症状显著减轻。白藜芦醇治疗显著降低了血液中IgE、IL - 4、TNF - α和嗜酸性粒细胞水平。此外还发现白藜芦醇治疗改善了AR成年患者 的生活质量。
我们的初步研究表明，鼻内使用白藜芦醇能够显著改善AR成年患者的鼻部症状。
