Ji X Q, Zhang N K
Department of Otolaryngology,Qingdao Economic and Technological Development Area First People's Hospital, Qingdao, 266555,China.
Department of Otolaryngology,Affiliated Hospital of Medical College of Qingdao University.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Apr 5;31(7):543-545. doi: 10.13201/j.issn.1001-1781.2017.07.012.
To identify the relationship between nasal secretion eosinophilia and pulmonary function of patients with AR after treatment of intranasal budesonide.Fifty patients with moderate to severe AR were selected, and compared to 50 normals, all had pulmonary function and nasal secretion of eosinophil number check, experimental group of AR received budesonide+loratadine treatment for 3 months, and then had lung function and nasal secretion eosinophil again, analysised the trends of change between two. Eosinophils of AR patients was higher than its of control group (<0.05), lung function index MMEF and nasal secretion eosinophilia of 50 AR patients had a negative relationship(=-0.945，<0.05).Treated with eosinophils the number of nasal secretion eosinophilia of AR decreased 10 + 5.6, the difference compared to the before of the treatment was statistically significant(<0.05), compared to the normal control group was significant(<0.05). After the treatment of budesonide, the trends of change between nasal secretion eosinophils and pulmonary function was a positive correlation(=0.803,<0.01). The higher the number of eosinophils in nasal secretions of patients with AR, the more obvious the decline of lung function. After the treatment with budesonide, the more eosinophils decreased in patients with AR, the more obvious the improvement of pulmonary function.
探讨鼻内应用布地奈德治疗后变应性鼻炎（AR）患者鼻分泌物嗜酸性粒细胞与肺功能的关系。选取50例中重度AR患者，并与50例正常人对照，均进行肺功能及鼻分泌物嗜酸性粒细胞计数检查，AR实验组给予布地奈德+氯雷他定治疗3个月后，再次进行肺功能及鼻分泌物嗜酸性粒细胞检查，分析两者变化趋势。AR患者嗜酸性粒细胞高于对照组（<0.05），50例AR患者肺功能指标最大呼气中期流速（MMEF）与鼻分泌物嗜酸性粒细胞呈负相关（r=-0.945，<0.05）。经治疗AR患者鼻分泌物嗜酸性粒细胞数下降10±5.6，与治疗前比较差异有统计学意义（<0.05），与正常对照组比较差异有统计学意义（<0.05）。布地奈德治疗后，鼻分泌物嗜酸性粒细胞与肺功能变化趋势呈正相关（r=0.803，<0.01）。AR患者鼻分泌物嗜酸性粒细胞数越高，肺功能下降越明显。布地奈德治疗后，AR患者嗜酸性粒细胞下降越多，肺功能改善越明显。
