Moradi Shabnam, Khazaei Hosna, Tarlan Mitra, Jasemi Seyed Vahid, Joshi Tanuj, Aneva Ina Yosifova, Farzaei Mohammad Hosein, Echeverría Javier
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Internal Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Front Pharmacol. 2024 Sep 30;15:1447097. doi: 10.3389/fphar.2024.1447097. eCollection 2024.
Allergic rhinitis is an inflammatory disease dependent on immunoglobulin E and causes inflammation of the nasal mucosa, leading to decreased quality of life for affected patients. Since common treatments, including corticosteroids and antihistamines, have temporary therapeutic effects and numerous side effects, investigating natural compounds effective in improving allergic rhinitis with low complications and high efficacy can be significant and necessary.
This study aims to present a comprehensive and critical evaluation of the effect of natural compounds in improving allergic rhinitis.
Studies were identified through systematic searches of ScienceDirect, PubMed, Scopus, and Web of Sciences databases. Eligibility checks were conducted based on predefined selection criteria. Forty-six articles were included in this study.
Phytochemicals, including flavonoids, alkaloids, terpenoids, and other compounds showed significant anti-inflammatory and antihistaminic effects. These compounds alleviate allergic rhinitis symptoms by inhibiting inflammatory mediators, oxidative stress, apoptosis, and key signaling pathways such as MAPK/NFκB and TLR4/MyD88/NF-κB.
Phytochemicals exhibit anti-inflammatory and antioxidant properties, making them.
过敏性鼻炎是一种依赖免疫球蛋白E的炎症性疾病，会导致鼻黏膜炎症，从而降低受影响患者的生活质量。由于包括皮质类固醇和抗组胺药在内的常见治疗方法具有暂时的治疗效果且有众多副作用，因此研究有效改善过敏性鼻炎且并发症少、疗效高的天然化合物具有重要意义且很有必要。
本研究旨在对天然化合物改善过敏性鼻炎的效果进行全面且批判性的评估。
通过对科学Direct、PubMed、Scopus和科学网数据库进行系统检索来确定研究。根据预先定义的选择标准进行资格审查。本研究纳入了46篇文章。
植物化学物质，包括黄酮类、生物碱、萜类和其他化合物，显示出显著的抗炎和抗组胺作用。这些化合物通过抑制炎症介质、氧化应激、细胞凋亡以及关键信号通路（如MAPK/NFκB和TLR4/MyD88/NF-κB）来缓解过敏性鼻炎症状。
植物化学物质具有抗炎和抗氧化特性，使其……
