Jeffcoat M K
J Periodontol. 1992 Dec;63 Suppl 12S:1045-1051. doi: 10.1902/jop.1992.63.12s.1045.
Periodontitis and gingivitis trials can involve many complex experimental designs. The selection of a specific design and the details of the protocol can influence the magnitude of any effect observed, the generalizability of the results, and the clinical significance of the findings. The purpose of this paper is to review selected aspects of clinical trials including the overall clinical experimental design, controls, outcomes, sample size, and patient selection. Particular emphasis will be placed on Periodontitis trials. J Periodontol 1992; 63:1045-1051.
牙周炎和牙龈炎试验可能涉及许多复杂的实验设计。特定设计的选择和方案细节会影响所观察到的任何效应的大小、结果的可推广性以及研究结果的临床意义。本文旨在回顾临床试验的某些方面，包括整体临床实验设计、对照、结局、样本量和患者选择。将特别强调牙周炎试验。《牙周病学杂志》1992年；63:1045 - 1051。
