Pradeep A R, Agarwal Esha, Bajaj Pavan, Naik Savitha B, Kumari Minal, Guruprasad C N
Department of Periodontics, Government Dental College and Research Institute, Fort, Bangalore, Karnataka, India.
Contemp Clin Dent. 2012 Jul;3(3):265-70. doi: 10.4103/0976-237X.103616.
The inability of the normal adult population to perform adequate tooth brushing has led to the search for chemotherapeutic agents in order to improve plaque control. This 6 month, single center, randomized controlled clinical trial was conducted to assess the clinical and microbiological effects of a dentifrice containing only amine fluoride (AF) as the active ingredient on gingivitis.
NINETY SUBJECTS DIAGNOSED WITH CHRONIC GENERALIZED GINGIVITIS WERE SELECTED AND RANDOMLY DIVIDED IN THREE GROUPS: Group 1 - placebo toothpaste, Group 2 - AF containing toothpaste, and Group 3 - triclosan containing toothpaste with polymer and fluoride. Clinical evaluation was undertaken using the gingival index of Loe and Silness and the plaque index and microbiological counts were assessed at baseline, 6 weeks, 12 weeks, and 24 weeks. A subjective evaluation was also undertaken by a questionnaire.
AF containing toothpaste showed significant improvement in gingival and plaque index scores as well as microbiologic counts compared with placebo dentifrice. These improvements were comparable to triclosan containing toothpaste.
AF containing toothpaste may be a useful formulation for chemical plaque control agent and improvement in plaque and gingival status and add to the list of various therapeutic agents used for maintenance of gingival health.
正常成年人群无法进行充分的刷牙，这促使人们寻找化学治疗剂以改善牙菌斑控制。本为期6个月的单中心随机对照临床试验旨在评估仅含胺氟（AF）作为活性成分的牙膏对牙龈炎的临床和微生物学影响。
选取90名被诊断为慢性广泛性牙龈炎的受试者，随机分为三组：第1组 - 安慰剂牙膏组，第2组 - 含AF牙膏组，第3组 - 含三氯生及聚合物和氟化物的牙膏组。使用Loe和Silness牙龈指数进行临床评估，并在基线、6周、12周和24周时评估牙菌斑指数和微生物计数。还通过问卷调查进行主观评估。
与安慰剂牙膏相比，含AF牙膏在牙龈和牙菌斑指数评分以及微生物计数方面有显著改善。这些改善与含三氯生牙膏相当。
含AF牙膏可能是一种有用的化学牙菌斑控制剂配方，可改善牙菌斑和牙龈状况，并增加用于维持牙龈健康的各种治疗剂种类。
