Carlson S E, Rhodes P G, Rao V S, Goldgar D E
Pediatr Res. 1987 May;21(5):507-10. doi: 10.1203/00006450-198705000-00017.
Very low birth weight infants demonstrate significant reductions in red blood cell membrane docosahexaenoic acid (DHA, 22:6n-3) following delivery unless fed human milk. The purpose of the present study was to determine if a dietary source of DHA (MaxEPA, R. P. Scherer Corporation, Troy, MI) could prevent the decline in red blood cell phospholipid DHA in very low birth weight infants whose enteral feeding consisted of a preterm formula without DHA. Longitudinal data were obtained on membrane phospholipid DHA in both unsupplemented and MaxEPA-supplemented infants by a combination of thin-layer and gas chromatography. These infants (n = 39) ranged in age from 10 to 53 days at enrollment (0 time). At enrollment, phospholipid DHA and arachidonic acid (20:4n-6) were inversely correlated with age in days. During the study, mean red blood cell phospholipid DHA declined without supplementary DHA as determined by biweekly measurement, but infants supplemented with MaxEPA maintained the same weight percent of phospholipid (phosphatidylethanolamine, phosphatidylcholine, and phosphatidylserine) DHA as at enrollment. The pattern of red blood cell phospholipid fatty acids in supplemented infants was similar to that reported for preterm infants fed human milk.
极低出生体重儿若不喂哺母乳，出生后红细胞膜二十二碳六烯酸（DHA，22:6n - 3）会显著减少。本研究的目的是确定膳食来源的DHA（MaxEPA，R.P. Scherer公司，密歇根州特洛伊市）能否预防极低出生体重儿红细胞磷脂DHA的下降，这些婴儿的肠内喂养采用不含DHA的早产配方奶。通过薄层色谱法和气相色谱法相结合，获取了未补充DHA和补充MaxEPA的婴儿红细胞膜磷脂DHA的纵向数据。这些婴儿（n = 39）入组时（0时间点）年龄在10至53天之间。入组时，磷脂DHA和花生四烯酸（20:4n - 6）与日龄呈负相关。在研究期间，通过每两周测量发现，未补充DHA时，红细胞磷脂DHA的平均值下降，但补充MaxEPA的婴儿维持了与入组时相同的磷脂（磷脂酰乙醇胺、磷脂酰胆碱和磷脂酰丝氨酸）DHA重量百分比。补充DHA的婴儿红细胞磷脂脂肪酸模式与喂哺母乳的早产儿报道相似。
