• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

微循环障碍及血必净在重症中暑中的保护作用。

Microcirculatory Disorders and Protective Role of Xuebijing in Severe Heat Stroke.

机构信息

Department of ICU, General Hospital of Guangzhou Military Command, Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of PLA, Guangzhou, 510010, China.

The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510000, China.

出版信息

Sci Rep. 2018 Mar 14;8(1):4553. doi: 10.1038/s41598-018-22812-w.

DOI:10.1038/s41598-018-22812-w
PMID:29540802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5852149/
Abstract

This study was conducted to explore underlying mechanism of microcirculation dysfunction and protectiverole of Xuebijing in heat stroke. Forty rats were divided into: control, vehicle + heat stress (HS), superoxide dismutase (SOD) + HS, and Xuebijing + HS groups. Rats in heat stress groups were subjected to continuous heat stress in infant incubator 1 h after tail vein injection of the tested compound and spinotrapezius preparation. Velocity of blood flow through micro-vessels and vascular diameter were detected in real time. Another 27 rats were divided into: vehicle, SOD, and Xuebijing groups, then further divided into three subgroups each: control, Tcore = 38 °C, Tcore = 41 °C. Rats were sacrificed, and spinotrapezius single-cell suspensions were prepared for detecting SOD and reactive oxygen species (ROS). The results showed that heat stress decreased SOD activity, increased ROS levels, and reduced the blood flow rate. Xuebijing increased SOD activity, decreased ROS levels and exhibited a protective effect in terms of blood flow rate but was less protective than SOD. The survival time in Xuebijing + HS group was longer than that in vehicle group but shorter than that in SOD + HS group. The results suggested Xuebijing could decrease ROS levels and have protective effects in severe heat stroke.

摘要

本研究旨在探讨微循环功能障碍的潜在机制及血必净在中暑中的保护作用。将 40 只大鼠分为：对照组、 vehicle+HS 组、SOD+HS 组和 Xuebijing+HS 组。HS 组大鼠在尾静脉注射受试化合物和斜方肌制剂后 1 小时，置于婴儿培养箱中进行持续热应激。实时检测微血管血流速度和血管直径。另外 27 只大鼠分为：vehicle 组、SOD 组和 Xuebijing 组，每组再分为 3 个亚组：对照组、Tcore=38°C、Tcore=41°C。处死大鼠，制备斜方肌单细胞悬液，检测 SOD 和活性氧（ROS）。结果表明，热应激降低 SOD 活性，增加 ROS 水平，降低血流速度。血必净可增加 SOD 活性，降低 ROS 水平，并在血流速度方面具有保护作用，但不如 SOD 保护作用强。Xuebijing+HS 组的存活时间长于 vehicle 组，但短于 SOD+HS 组。结果提示血必净可降低 ROS 水平，对重症中暑具有保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8966/5852149/b0fa116ac8df/41598_2018_22812_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8966/5852149/7a0e942e1dca/41598_2018_22812_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8966/5852149/1af1ac629847/41598_2018_22812_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8966/5852149/821091a09025/41598_2018_22812_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8966/5852149/7633abc17554/41598_2018_22812_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8966/5852149/1ace366809c2/41598_2018_22812_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8966/5852149/803121d66ba8/41598_2018_22812_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8966/5852149/b0fa116ac8df/41598_2018_22812_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8966/5852149/7a0e942e1dca/41598_2018_22812_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8966/5852149/1af1ac629847/41598_2018_22812_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8966/5852149/821091a09025/41598_2018_22812_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8966/5852149/7633abc17554/41598_2018_22812_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8966/5852149/1ace366809c2/41598_2018_22812_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8966/5852149/803121d66ba8/41598_2018_22812_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8966/5852149/b0fa116ac8df/41598_2018_22812_Fig7_HTML.jpg

相似文献

1
Microcirculatory Disorders and Protective Role of Xuebijing in Severe Heat Stroke.微循环障碍及血必净在重症中暑中的保护作用。
Sci Rep. 2018 Mar 14;8(1):4553. doi: 10.1038/s41598-018-22812-w.
2
Microcirculatory Disorders and Protective Role of Antioxidant in Severe Heat Stroke: A Rat Study.微循环障碍与抗氧化剂在重症中暑中的保护作用：一项大鼠研究
Shock. 2016 Dec;46(6):688-695. doi: 10.1097/SHK.0000000000000623.
3
[Pretreatment with Xuebijing injection alleviates systemic inflammatory response induced by severe heat-stroke via ameliorating intestinal injury in rats].[血必净注射液预处理通过改善大鼠肠道损伤减轻重症中暑诱导的全身炎症反应]
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Aug;27(8):643-8. doi: 10.3760/cma.j.issn.2095-4352.2015.08.005.
4
Xuebijing injection alleviates liver injury by inhibiting secretory function of Kupffer cells in heat stroke rats.血必净注射液通过抑制热射病大鼠库普弗细胞的分泌功能减轻肝损伤。
J Tradit Chin Med. 2013 Apr;33(2):243-9. doi: 10.1016/s0254-6272(13)60133-8.
5
[Protective effects of xuebijing on the acute lung injury in rats].血必净对大鼠急性肺损伤的保护作用
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2017 Feb 8;33(2):132-135. doi: 10.12047/j.cjap.5464.2017.034.
6
[Effect of Xuebijing injection on hemodynamics and endothelial function in patients with severe sepsis: a prospective study].血必净注射液对严重脓毒症患者血流动力学及内皮功能的影响：一项前瞻性研究
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Feb;27(2):127-32. doi: 10.3760/cma.j.issn.2095-4352.2015.02.010.
7
[Exploration of the mechanism of xinfeng capsule in the treatment of ankylosing spondylitis based on B and T lymphocyte attenuator and oxidative stress].基于B和T淋巴细胞衰减器及氧化应激探讨新风胶囊治疗强直性脊柱炎的机制
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2015 Jan;35(1):25-32.
8
Effects of Xuebijing injection on microcirculation in septic shock.血必净注射液对脓毒性休克微循环的影响。
J Surg Res. 2016 May 1;202(1):147-54. doi: 10.1016/j.jss.2015.12.041. Epub 2015 Dec 30.
9
Protective effect of Xuebijing injection on paraquat-induced pulmonary injury via down-regulating the expression of p38 MAPK in rats.血必净注射液通过下调大鼠p38丝裂原活化蛋白激酶表达对百草枯诱导的肺损伤的保护作用
BMC Complement Altern Med. 2014 Dec 16;14:498. doi: 10.1186/1472-6882-14-498.
10
Xuebijing injection attenuates pulmonary injury by reducing oxidative stress and proinflammatory damage in rats with heat stroke.血必净注射液通过减轻热射病大鼠的氧化应激和促炎损伤来减轻肺损伤。
Exp Ther Med. 2017 Jun;13(6):3408-3416. doi: 10.3892/etm.2017.4444. Epub 2017 May 8.

引用本文的文献

1
Xuebijing Promotes HMGB1-Mediated Autophagy to Alleviate Oxidative Stress and Inflammation in Heat Stroke-Induced Brain Damage.血必净通过促进HMGB1介导的自噬减轻中暑诱导的脑损伤中的氧化应激和炎症反应。
Mol Neurobiol. 2025 Jun 23. doi: 10.1007/s12035-025-05120-z.
2
Xuebijing Exerts Protective Effects on Myocardial Cells by Upregulating TRIM16 and Inhibiting Oxidative Stress and Apoptosis.血必净通过上调TRIM16和抑制氧化应激及细胞凋亡对心肌细胞发挥保护作用。
Curr Comput Aided Drug Des. 2025;21(4):503-516. doi: 10.2174/0115734099318323241122184120.
3
Xuebijing Injection Attenuates Heat Stroke-Induced Brain Injury through Oxidative Stress Blockage and Parthanatos Modulation via PARP-1/AIF Signaling.

本文引用的文献

1
Microcirculatory Disorders and Protective Role of Antioxidant in Severe Heat Stroke: A Rat Study.微循环障碍与抗氧化剂在重症中暑中的保护作用：一项大鼠研究
Shock. 2016 Dec;46(6):688-695. doi: 10.1097/SHK.0000000000000623.
2
Propionyl-L-Carnitine Enhances Wound Healing and Counteracts Microvascular Endothelial Cell Dysfunction.丙酰-L-肉碱促进伤口愈合并对抗微血管内皮细胞功能障碍。
PLoS One. 2015 Oct 16;10(10):e0140697. doi: 10.1371/journal.pone.0140697. eCollection 2015.
3
Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator.
血必净注射液通过阻断氧化应激和经由PARP-1/AIF信号通路调节parthanatos减轻中暑诱导的脑损伤。
ACS Omega. 2023 Sep 6;8(37):33392-33402. doi: 10.1021/acsomega.3c03084. eCollection 2023 Sep 19.
4
miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway regulates the heat‑stress‑induced apoptosis of endothelial cells.miR-3613-3p/MAP3K2/p38/caspase-3 通路调控内皮细胞热应激诱导的细胞凋亡。
Mol Med Rep. 2021 Sep;24(3). doi: 10.3892/mmr.2021.12272. Epub 2021 Jul 19.
5
Chinese Patent Medicines in the Treatment of Coronavirus Disease 2019 (COVID-19) in China.中成药在中国治疗新型冠状病毒肺炎（COVID-19）中的应用
Front Pharmacol. 2020 Jul 17;11:1066. doi: 10.3389/fphar.2020.01066. eCollection 2020.
6
The clinical benefits of Chinese patent medicines against COVID-19 based on current evidence.基于现有证据的抗 COVID-19 中药的临床获益。
Pharmacol Res. 2020 Jul;157:104882. doi: 10.1016/j.phrs.2020.104882. Epub 2020 May 5.
7
Xuebijing Injection Maintains GRP78 Expression to Prevent -Induced Epithelial Death in the Kidney.血必净注射液维持GRP78表达以预防顺铂诱导的肾上皮细胞死亡。
Front Pharmacol. 2020 Jan 6;10:1416. doi: 10.3389/fphar.2019.01416. eCollection 2019.
虎杖苷作为一种SIRT1激活剂可减轻失血性休克期间的小肠损伤。
Oxid Med Cell Longev. 2015;2015:965961. doi: 10.1155/2015/965961. Epub 2015 Aug 2.
4
Physical Effort Affects Heatstroke Thermoregulatory Response and Mortality in Rats.体力活动影响大鼠中暑体温调节反应及死亡率。
Shock. 2015 Aug;44(2):149-56. doi: 10.1097/SHK.0000000000000387.
5
Heat stroke.中暑。
Compr Physiol. 2015 Apr;5(2):611-47. doi: 10.1002/cphy.c140017.
6
What is microcirculatory shock?什么是微循环休克？
Curr Opin Crit Care. 2015 Jun;21(3):245-52. doi: 10.1097/MCC.0000000000000196.
7
[Resveratrol improves intestinal injury in hemorrhagic shock rats by protection of mitochondria and reduction of oxidative stress].白藜芦醇通过保护线粒体和减轻氧化应激改善失血性休克大鼠的肠道损伤
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2014 Dec;39(12):1259-65. doi: 10.11817/j.issn.1672-7347.2014.12.007.
8
Monitoring the microcirculation in critically ill patients.监测危重症患者的微循环。
Best Pract Res Clin Anaesthesiol. 2014 Dec;28(4):441-51. doi: 10.1016/j.bpa.2014.09.005. Epub 2014 Sep 28.
9
Ubiquinol decreases hemorrhagic shock/resuscitation-induced microvascular inflammation in rat mesenteric microcirculation.泛醇可减轻大鼠肠系膜微循环中出血性休克/复苏诱导的微血管炎症。
Physiol Rep. 2014 Nov 20;2(11). doi: 10.14814/phy2.12199. Print 2014 Nov 1.
10
Carbon monoxide protects against hemorrhagic shock and resuscitation-induced microcirculatory injury and tissue injury.一氧化碳可预防失血性休克以及复苏诱导的微循环损伤和组织损伤。
Shock. 2015 Feb;43(2):166-71. doi: 10.1097/SHK.0000000000000264.