Gul Amara, Zafar Sadia
The Islamia University of Bahawalpur.
J Pak Med Assoc. 2018 Mar;68(3):848-486.
The objective of the current study was to compare cognitive flexibility and emotion regulation between childhood survivors of Acute Lymphoblastic Leukaemia (ALL) and healthy control subjects. Twenty-five childhood survivors of ALL treated with intrathecal chemotherapy between 2013 to 2016 from Shaukat Khanum Memorial Cancer Hospital, Children Hospital and Jinnah Hospital Lahore and twenty-five healthy demographically matched children (control group) participated in the study. Participants performed task switching experiment as a measure of cognitive flexibility and emotion regulation questionnaire for children and adolescents. In contrast to healthy control group, ALL survivors showed impaired cognitive flexibility and emotion regulation. Results have implications for cognitive rehabilitation to improve functions of frontal-cerebellar system in childhood survivors of ALL.
本研究的目的是比较急性淋巴细胞白血病（ALL）儿童幸存者与健康对照受试者之间的认知灵活性和情绪调节能力。2013年至2016年间，来自拉合尔的沙卡特·汗姆纪念癌症医院、儿童医院和真纳医院的25名接受鞘内化疗的ALL儿童幸存者以及25名在人口统计学上匹配的健康儿童（对照组）参与了该研究。参与者进行了任务转换实验，作为认知灵活性的一种测量方法，并填写了儿童和青少年情绪调节问卷。与健康对照组相比，ALL幸存者表现出认知灵活性和情绪调节能力受损。研究结果对认知康复具有启示意义，有助于改善ALL儿童幸存者的额小脑系统功能。
