Chouty F, Funck-Brentano C, Landau J M, Lardoux H
Presse Med. 1987 May 9;16(17):808-10.
Three cases of intoxication by flecainide acetate were characterized by cardiovascular collapse with widening of the QRS complex at electrocardiography. In two of these patients, impairment of liver or renal function probably played a facilitating role. Infusion of molar sodium lactate in high doses resulted in rapid and durable clinical and electrocardiographic improvement. This effect of molar sodium lactate may tentatively be attributed to either displacement of flecainide from its tissue receptor sites, or to a decrease in the effect of flecainide by alteration of its action on the fast sodium channel, or to the beneficial effects of vascular filling.
三例醋酸氟卡尼中毒的特征为心血管性虚脱，心电图显示QRS波群增宽。其中两名患者，肝功能或肾功能损害可能起到了促进作用。大剂量输注摩尔乳酸钠导致临床和心电图迅速且持久地改善。摩尔乳酸钠的这种作用可能初步归因于氟卡尼从其组织受体部位的置换，或通过改变其对快钠通道的作用来降低氟卡尼的效应，或归因于血管充盈的有益作用。
