用于感染动物模型中强效光动力抗菌作用及伤口愈合的家用光源。
Household light source for potent photo-dynamic antimicrobial effect and wound healing in an infective animal model.
作者信息
Ullah Azeem, Zhang Yuxiang, Iqbal Zafar, Zhang Yaxin, Wang Dong, Chen Jincan, Hu Ping, Chen Zhuo, Huang Mingdong
机构信息
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 West Yangqiao Road, Fuzhou, Fujian, China, 350002.
University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing, China, 100049.
出版信息
Biomed Opt Express. 2018 Feb 6;9(3):1006-1019. doi: 10.1364/BOE.9.001006. eCollection 2018 Mar 1.
Photodynamic antimicrobial chemotherapy (PACT) is considered a promising alternative to conventional antibiotic approach. We have previously developed a novel PS containing five lysine amino acids, pentalysine-β-carbonylphthalocyanine Zinc (ZnPc(Lys)), which in the presence of light, is highly toxic against a range of bacterial strains, including hospital isolated, drug resistant Acinetobacter baumannii. Here, we study the effect of light fluence of the two light sources on the PACT potency of ZnPc(Lys). We observed that an exposure of to a red LED light for only 2 seconds (light fluence of 0.15 J/cm) in the presence of ZnPc(Lys) significantly eradicated 80% of the . We further demonstrated that a light fluence of 4.5 J/cm from a household light source induced a noticeable photodynamic effect in vitro and in vivo animal model. This study points to a new research direction of reducing light illumination time by increasing potency of PS.
光动力抗菌化疗（PACT）被认为是传统抗生素方法的一种有前景的替代方法。我们之前开发了一种含有五个赖氨酸氨基酸的新型光敏剂，五赖氨酸-β-羰基酞菁锌（ZnPc(Lys)），其在光照下对一系列细菌菌株具有高度毒性，包括医院分离的耐药鲍曼不动杆菌。在此，我们研究了两种光源的光通量对ZnPc(Lys)的PACT效力的影响。我们观察到，在ZnPc(Lys)存在的情况下，仅用红色LED灯照射2秒（光通量为0.15 J/cm）就能显著根除80%的[细菌名称未给出]。我们进一步证明，来自家用光源的4.5 J/cm的光通量在体外和体内动物模型中都诱导了明显的光动力效应。这项研究指出了一个通过提高光敏剂效力来减少光照时间的新研究方向。
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